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中华危重症医学杂志(电子版) ›› 2023, Vol. 16 ›› Issue (02) : 134 -136. doi: 10.3877/cma.j.issn.1674-6880.2023.02.008

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马来酸氟伏沙明中毒一例并文献复习
范致远, 桂胜昊, 徐文祥, 高海威, 肖正武, 郁慧杰()   
  1. 314500 浙江桐乡,桐乡市第一人民医院急诊科
    314500 浙江桐乡,桐乡市第一人民医院重症医学科
    314001 浙江嘉兴,嘉兴市第一医院急诊科
  • 收稿日期:2023-02-27 出版日期:2023-04-30
  • 通信作者: 郁慧杰
  • Received:2023-02-27 Published:2023-04-30
引用本文:

范致远, 桂胜昊, 徐文祥, 高海威, 肖正武, 郁慧杰. 马来酸氟伏沙明中毒一例并文献复习[J]. 中华危重症医学杂志(电子版), 2023, 16(02): 134-136.

氟伏沙明为一种选择性5-羟色胺再摄取抑制剂(selective serotonin reuptake inhibitors,SSRIs),是目前治疗抑郁症和强迫症的一线药物。与三环类抗抑郁药及单胺氧化酶抑制剂相比,SSRIs类药物不良反应更少,更加安全[1-2]。氟伏沙明临床登记注册于1983年,而且是被食品药品监督管理局(Food and Drug Administration,FDA)批准应用于治疗强迫症的非三环类抗抑郁药,随后氟伏沙明被广泛应用于抑郁障碍、焦虑障碍及强迫障碍的治疗。目前虽然有氟伏沙明中毒的相关病例报道[3-5],但总体救治经验较少,本研究将报道1例马来酸氟伏沙明中毒的患者。

图1 马来酸氟伏沙明中毒患者血药浓度变化图
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