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中华危重症医学杂志(电子版) ›› 2022, Vol. 15 ›› Issue (05) : 425 -429. doi: 10.3877/cma.j.issn.1674-6880.2022.05.014

综述

七氟烷对失血性休克的器官保护作用与机制
李中华1, 郭睿1, 赵自刚1,()   
  1. 1. 075000 河北张家口,河北北方学院微循环研究所
  • 收稿日期:2022-01-05 出版日期:2022-10-31
  • 通信作者: 赵自刚
  • 基金资助:
    国家自然科学基金面上项目(81770492)
  • Received:2022-01-05 Published:2022-10-31
引用本文:

李中华, 郭睿, 赵自刚. 七氟烷对失血性休克的器官保护作用与机制[J]. 中华危重症医学杂志(电子版), 2022, 15(05): 425-429.

失血性休克是创伤、产后出血、消化道出血、围术期出血和动脉瘤破裂等严重失血因素引起的以微循环低灌注为特征、以细胞损伤和器官功能障碍为严重后果的危重病理过程,是35岁以下人群死亡的主要原因[1,2]。若不能及时有效地控制出血、恢复内环境稳态,失血性休克则会引起过度的炎症反应、细胞凋亡、氧化应激,继而引发多器官功能障碍综合征,严重威胁患者的生命[3]。七氟醚在临床上用于吸入麻醉已超过20年,其安全性和有效性已普遍得到公认。七氟烷具有多种药理学作用,除了作为全身麻醉药物应用于手术患者的麻醉外,还广泛应用于一些疾病的临床治疗。由于七氟烷可引起血压降低、心动过速等不良反应,故很少有研究者将七氟烷与防治失血性休克联系在一起。但在失血性休克液体管理过程中,需要时机性地选择血管活性药物,这使得研究者开始关注七氟烷预处理或后处理对失血性休克的作用。为此,本文综述七氟烷在失血性休克发展进程中的器官保护作用与机制。

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