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中华危重症医学杂志(电子版) ›› 2017, Vol. 10 ›› Issue (04) : 230 -234. doi: 10.3877/cma.j.issn.1674-6880.2017.04.004

所属专题: 文献

营养与代谢

鼻胃管减压联合鼻肠管营养支持对重症神经系统疾病患者预后的影响
潘小东1, 张京臣2, 汤鲁明1, 孙来芳1,()   
  1. 1. 325027 浙江温州,温州医科大学附属第二医院急诊科
    2. 310003 杭州,浙江大学医学院附属第一医院急诊科
  • 收稿日期:2017-04-30 出版日期:2017-08-01
  • 通信作者: 孙来芳
  • 基金资助:
    浙江省温州市科技计划项目(Y20140077)

Effect of nasogastric tube decompression combined with nasointestinal tube nutritional support in the prognosis of patients with severe nervous system diseases

Xiaodong Pan1, Jingchen Zhang2, Luming Tang1, Laifang Sun1,()   

  1. 1. Department of Emergency Medicine, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China
    2. Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
  • Received:2017-04-30 Published:2017-08-01
  • Corresponding author: Laifang Sun
  • About author:
    Corresponding author: Sun Laifang, Eamil: sunlaifang@163.com
引用本文:

潘小东, 张京臣, 汤鲁明, 孙来芳. 鼻胃管减压联合鼻肠管营养支持对重症神经系统疾病患者预后的影响[J]. 中华危重症医学杂志(电子版), 2017, 10(04): 230-234.

Xiaodong Pan, Jingchen Zhang, Luming Tang, Laifang Sun. Effect of nasogastric tube decompression combined with nasointestinal tube nutritional support in the prognosis of patients with severe nervous system diseases[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2017, 10(04): 230-234.

目的

评估胃管减压联合鼻肠管营养支持对重症神经系统疾病患者预后的影响。

方法

将90例患者分为鼻肠管组和鼻胃管组,每组各45例。收集两组患者入组时急性病生理学和长期健康评价(APACHE)Ⅱ评分及格拉斯哥昏迷评分(GCS);收集每例患者治疗后1、7、14 d白蛋白水平及肠内营养热卡;记录并比较各组患者并发症的发生情况及机械通气时间、ICU住院时间、总住院时间、病死率情况。

结果

鼻肠管组及鼻胃管组患者APACHEⅡ评分[(20.5 ± 6.4)分vs.(20.3 ± 6.9)分]、GCS评分[(6.1 ± 1.3)分vs.(5.5 ± 1.5)分]间比较,差异均无统计学意义(t = 0.140、0.270,P = 0.888、0.787)。鼻肠管组患者治疗后14 d的血白蛋白水平[(37.5 ± 2.8)g/L vs.(34.2 ± 5.6)g/L]及获得肠内营养热卡[(2 147 ± 625)kcal vs.(1 791 ± 768)kcal]较鼻胃管组显著升高(t = 3.548、2.412,P = 0.001、0.017)。同时,鼻肠管组患者吸入性肺炎(5/45 vs. 20/45)、营养液潴留(3/45 vs. 19/45)的发生率显著低于鼻胃管组患者(χ2 = 12.462、15.401,P = 0.001、0.001)。而两组患者在机械通气时间(t = 1.149,P = 0.253)、ICU住院时间(t = 0.763,P = 0.447)、总住院时间(t = 1.251,P = 0.214)及病死率(χ2 = 0.403,P = 0.525)的比较,差异均无统计学意义。

结论

对于重症神经系统患者早期进行胃管减压联合鼻空肠管营养更能有效改善其营养状况、减少并发症的发生,对改善患者预后有一定的临床价值。

Objective

To evaluate the effect of nasogastric tube decompression combined with nasointestinal tube nutritional support in the prognosis of patients with severe nervous system diseases.

Methods

A total of 90 patients with severe nervous system diseases were divided into the nasointestinal tube group (n = 45) and the nasogastric tube group (n = 45). The acute physiology and chronic health evaluation (APACHE) Ⅱ and Glasgow coma scale (GCS) were calculated after the patients were recruited into the groups. The levels of albumin and calories gained from enteral nutrition were determined on 1, 7, 14 d after treatment. The incidence of complications, duration of mechanical ventilation, length of ICU stay, total length of hospital stay and mortality rate were also recorded and compared between these two groups.

Results

The APACHE Ⅱ scores [(20.5 ± 6.4) vs. (20.3 ± 6.9)] and GCS scores [(6.1 ± 1.3) vs. (5.5 ± 1.5)] all showed no significant differences in the nasointestinal tube group and the nasogastric tube group (t = 0.140, 0.270; P = 0.888, 0.787). The levels of albumin [(37.5 ± 2.8) g/L vs. (34.2 ± 5.6) g/L] and calories gained from enteral nutrition [(2 147 ± 625) kcal vs. (1 791 ± 768) kcal] on 14 d after treatment in the nasointestinal tube group were both much higher than those in the nasogastric tube group (t = 3.548, 2.412; P = 0.001, 0.017). Meanwhile, the incidence of aspiration pneumonia (5/45 vs. 20/45) and nutrient fluid retention (3/45 vs. 19/45) in the nasointestinal tube group were much lower than those in the nasogastric tube group (χ2 = 12.462, 15.401; P = 0.001, 0.001). However, there were no significant differences in the duration of mechanical ventilation (t = 1.149, P = 0.253), length of ICU stay (t = 0.763, P = 0.447), total length of hospital stay (t = 1.251, P = 0.214) and mortality rate (χ2 = 0.403, P = 0.525) between the two groups.

Conclusion

Nasogastric tube decompression combined with nasointestinal tube nutritional support at the early stage can improve nutritional status and reduce complications in patients with severe nervous system diseases.

表1 两组重症神经系统疾病患者临床指标的比较( ± s
表2 两组重症神经系统疾病患者并发症及相关终点指标的比较( ± s
1
Steiner T, Kaste M, Forsting M, et al. Recommendations for the management of intracranial haemorrhage-part I: spontaneous intracerebral haemorrhage. The European Stroke Initiative Writing Committee and the Writing Committee for the EUSI Executive Committee[J]. Cerebrovasc Dis, 2006, 22 (4): 294-316.
2
Steiner T, Al-Shahi Salman R, Beer R, et al. European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage[J]. Int J Stroke, 2014, 9 (7): 840-855.
3
Liu M, Wu B, Wang WZ, et al. Stroke in China: epidemiology, prevention, and management strategies[J]. Lancet Neurol, 2007, 6 (5): 456-464.
4
Zhao D, Liu J, Wang W, et al. Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project[J]. Stroke, 2008, 39 (6): 1668-1674.
5
魏红玲. 重型颅脑损伤治疗早期肠内营养支持的效果观察[J]. 中国实用神经疾病志,2009,12(14):80-81.
6
Minard G, Kudsk KA, Melton S, et al. Early versus delayed feeding with an immune-enhancing diet in patients with severe head injuries[J]. JPEN J Parenter Enteral Nutr, 2000, 24 (3): 145-149.
7
Davies AR, Froomes PR, French CJ, et al. Randomized comparison of nasojejunal and nasogastric feeding in critically ill patients[J]. Crit Care Med, 2002, 30 (3): 586-590.
8
Acosta-Escribano J, Fernández-Vivas M, Grau CT, et al. Gastric versus transpyloric feeding in severe traumatic brain injury: a prospective, randomized trial[J]. Intensive Care Med, 2010, 36 (9): 1532-1539.
9
吕传真,周良辅. 实用神经病学[M]. 4版. 上海:科学技术出版社,2014.
10
蓝慧兰,陈纯波,黄碧灵,等. 双导丝螺旋型鼻肠管用于危重患者置管的方法和护理[J]. 中华护理杂志,2008,43(10):902-904.
11
Reintam BA, Malbrain ML, Starkopf J, et al. Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems[J]. Intensive Care Med, 2012, 38 (3): 384-394.
12
Oertel MF, Hauenschild A, Gruenschlaeger J, et al. Parenteral and enteral nutrition in the management of neurosurgical patients in the intensive care unit[J]. J Clin Neurosci, 2009, 16 (9): 1161-1167.
13
中华医学会神经外科学分会. 神经外科重症管理专家共识(2013版)[J]. 中华医学杂志,2013,93(23):1765-1779.
14
中华医学会肠外肠内营养学分会神经疾病营养支持学组. 神经系统疾病肠内营养支持操作规范共识(2011版)[J]. 中华神经科杂志,2011,44(11):787-791.
15
罗建江,王欣,马红霞. 不同肠内营养对呼吸机相关性肺炎的作用分析[J]. 临床肺科杂志,2013,18(7):1233-1234.
16
黎焯基,蔡必林,陈大勇. 鼻肠管和鼻胃管在机械通气患者应用中的不良反应比较[J]. 广东医学院学报,2011,29(6):657-658.
17
White H, Sosnowski K, Tran K, et al. A randomised controlled comparison of early post-pyloric versus early gastric feeding to meet nutritional targets in ventilated intensive care patient[J]. Crit Care, 2009, 13 (6): R187.
18
American Association of Neuroscience Nurses. Nursing management of adults with severe traumatic brain injury[M]. Glenview: American Association of Neuroscienee Nurses, 2008: 1-20.
19
潘小东,汤鲁明,孙来芳. 危重神经系统疾病患者肠内营养与胃内营养对预后影响的meta分析[J/CD]. 中华危重症医学杂志(电子版),2015,8(1):29-34.
20
Hsu CW, Sun SF, Lin SL, et al. Duodenal versus gastric feeding in medical intensive care unit patients: a prospective, randomized, clinical study[J]. Crit Care Med, 2009, 37 (6): 1866-1872.
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