Home    中文  
 
  • Search
  • lucene Search
  • Citation
  • Fig/Tab
  • Adv Search
Just Accepted  |  Current Issue  |  Archive  |  Featured Articles  |  Most Read  |  Most Download  |  Most Cited

Chinese Journal of Critical Care Medicine(Electronic Edition) ›› 2024, Vol. 17 ›› Issue (05): 379-384. doi: 10.3877/cma.j.issn.1674-6880.2024.05.004

• Original Articles • Previous Articles    

A single-center retrospective analysis of efficacy and safety of obinutuzumab for treating phospholipase A2 receptor associated membranous nephropathy

Qilong Zhang1,(), Yi Liu1, Huili Lu1, Hui Luo1, Chenglin Li1, Jing Wang1, Hui Wang2   

  1. 1.Department of Nephrology,People's Hospital of Anji(Anji Branch of the First Affiliated Hospital,Zhejiang University School of Medicine),Huzhou 313300,China
    2.Department of Pharmacy,People's Hospital of Anji(Anji Branch of the First Affiliated Hospital,Zhejiang University School of Medicine),Huzhou 313300,China
  • Received:2024-09-03 Online:2024-10-31 Published:2024-12-13
  • Contact: Qilong Zhang

Abstract:

Objective

To analyze the efficacy and safety of obinutuzumab in the treatment of patients with phospholipase A2 receptor (PLA2R) associated membranous nephropathy (MN).

Methods

It was a single-center retrospective observational study.The clinical data before and after obinutuzumab treatment of 12 patients with PLA2R associated MN in the Department of Nephrology of People's Hospital of Anji from April 2022 to November 2023 were retrospectively collected.The kidney relief situation and adverse reactions were analyzed.The treatment regimen was 1.0 g intravenous infusion of obinutuzumab initially, with or without additional dosage.The follow-up was up to March 12, 2024.

Results

All 12 patients had positive renal puncture pathology PLA2R staining and/or positive serum anti-PLA2R antibodies and were diagnosed with PLA2R associated MN.Ten patients were treated with a 2nd dose of obinutuzumab, one was treated in another hospital without a 2nd dose of obinutuzumab, and one was treated with an additional 3rd dose of obinutuzumab after eight months of treatment.None of the 12 patients experienced serious adverse events, and two had infections which were grade 3 by the common terminology criteria for adverse events.Grade 1 infusion related reactions (IRR) occurred in five patients during the initial treatment, which were alleviated after slowing down the infusion rate or symptomatic treatment, and they successfully completed the infusion.No IRR or adverse events occurred in subsequent infusions.Ten patients achieved remission after treatment, including four complete remissions, and the other two could not be evaluated for efficacy due to missing followup data.

Conclusion

Obinutuzumab treatment is effective for PLA2R associated MN in inducing kidney remission, with favorable safety.

Key words: Obinutuzumab, Receptors, phospholipase A2, Glomerulonephritis, membranous, Curative effect, Safety

京ICP 备07035254号-20
Copyright © Chinese Journal of Critical Care Medicine(Electronic Edition), All Rights Reserved.
Tel: 0571-87236467 E-mail: zhwzzyxzz@126.com
Powered by Beijing Magtech Co. Ltd