Effect of selective decontamination of digestive tract for non-infective trauma patients with procalcitonin elevation

doi:10.3877/cma.j.issn.1674-6880.2016.02.007

Abstract

Abstract:

Objective

To investigate the effect of selective decontamination of the digestive tract on the non-infective trauma patients with procalcitonin elevation.

Methods

A total of 80 non-infective trauma patients with procalcitonin elevation were randomly divided into the experiment group and control group, 40 cases in each group. The patients in the experiment group were treated with selective intestinal decontamination, and patients in the control group received normal saline at the same time. The levels of serum procalcitonin and endotoxin were monitored continuously. And the acute kidney injury (AKI) were assessed in the two groups.

Results

At 7, 9, 11, 13 d after treatment, the procalcitonin levels and the endotoxin levels were significantly lower in the experiment group than those in the control group (1.29 ± 0.26 vs. 3.90 ± 0.64, 0.89 ± 0.15 vs. 3.52 ± 0.45, 0.56 ± 0.16 vs. 3.98 ± 0.78, 0.50 ± 0.18 vs. 3.56 ± 0.08 μg/L, t=23.906, 35.279, 27.236, 36.406, all P<0.05; and 82±12 vs. 101 ± 18, 53 ± 8 vs. 113 ± 17, 47 ± 8 vs. 108 ± 13, 34 ± 6 vs. 96 ± 16 EU/L, t=5.705, 20.407, 24.989, 22.901, all P<0.05). Meanwhile, the rate of AKI in the control group were higher than those in the experiment group (27/40 vs. 15/40, χ²=7.218, P<0.05).

Conclusion

Our research further confirmed that the reason of non-infective trauma patients with procalcitonin elevation is belong to intestinal infection, and selective decontamination of digestive tract can be significantly reduced the level of procalcitonin and endotoxin, and thereby reduce the risk of AKI in follow-up treatment.

Key words: Selective intestinal decontamination, Non-infective trauma, Procalcitonin

Zhigang Zuo, Liu Pei, Degang Song, Weipeng Song, Xiujuan Liu, Fang Qiu. Effect of selective decontamination of digestive tract for non-infective trauma patients with procalcitonin elevation[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2016, 09(02): 105-108.

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References 20

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组别	例数	各时间点降钙素原水平
组别	例数	第1天	第3天	第5天	第7天	第9天	第11天	第13天
实验组	40	8.32 ± 1.34	11.18 ± 1.50	5.69 ± 1.00	1.29 ± 0.26	0.89 ± 0.15	0.56 ± 0.16	0.50 ± 0.18
对照组	40	8.69 ± 1.34	10.92 ± 1.34	5.61 ± 0.92	3.90 ± 0.64	3.52 ± 0.45	3.98 ± 0.78	3.56 ± 0.08
t值	?	1.264	0.378	0.378	23.906	35.276	27.236	36.406
P值	?	0.221	0.429	0.707	< 0.05	< 0.05	< 0.05	< 0.05

组别	例数	各时间点降钙素原水平
组别	例数	第1天	第3天	第5天	第7天	第9天	第11天	第13天
实验组	40	8.32 ± 1.34	11.18 ± 1.50	5.69 ± 1.00	1.29 ± 0.26	0.89 ± 0.15	0.56 ± 0.16	0.50 ± 0.18
对照组	40	8.69 ± 1.34	10.92 ± 1.34	5.61 ± 0.92	3.90 ± 0.64	3.52 ± 0.45	3.98 ± 0.78	3.56 ± 0.08
t值	?	1.264	0.378	0.378	23.906	35.276	27.236	36.406
P值	?	0.221	0.429	0.707	< 0.05	< 0.05	< 0.05	< 0.05

组别	例数	各时间点内毒素水平
组别	例数	第1天	第3天	第5天	第7天	第9天	第11天	第13天
实验组	40	158 ± 25	190 ± 28	145 ± 24	82 ± 12	53 ± 8	47 ± 8	34 ± 6
对照组	40	165 ± 19	185 ± 30	153 ± 22	101 ± 18	113 ± 17	108 ± 13	96 ± 16
t值	?	1.041	0.677	1.466	5.705	20.407	24.989	22.901
P值	?	0.165	0.500	0.547	< 0.05	< 0.05	< 0.05	< 0.05

组别	例数	各时间点内毒素水平
组别	例数	第1天	第3天	第5天	第7天	第9天	第11天	第13天
实验组	40	158 ± 25	190 ± 28	145 ± 24	82 ± 12	53 ± 8	47 ± 8	34 ± 6
对照组	40	165 ± 19	185 ± 30	153 ± 22	101 ± 18	113 ± 17	108 ± 13	96 ± 16
t值	?	1.041	0.677	1.466	5.705	20.407	24.989	22.901
P值	?	0.165	0.500	0.547	< 0.05	< 0.05	< 0.05	< 0.05

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