Incidence of venous thromboembolism in patients with obstructive sleep apnea syndrome: a meta-analysis

doi:10.3877/cma.j.issn.1674-6880.2024.04.007

Abstract

Abstract:

Objective

To systematically evaluate the incidence of venous thromboembolism (VTE) in patients with obstructive sleep apnea syndrome (OSAS).

Methods

Databases such as CNKI, Wanfang, VIP, Pubmed, Embase and Cochrane Library were searched for articles on the incidence of VTE in OSAS patients published up to March 24, 2023. Two researchers screened and evaluated literatures according to the inclusion and exclusion criteria. Data analysis was carried out using Stata 15.1.

Results

A total of 10 articles with 18 345 participants met the inclusion criteria for meta-analysis after filtering. Meta-analysis showed that the incidence of VTE in OSAS patients was 2.4% [95% confidence interval (1.3%, 3.7%)]. Further subgroup analysis showed that there was a statistically significant difference in the incidence of VTE in OSAS patients at home and abroad (Z = 6.912, P = 0.021).

Conclusions

The incidence of VTE varies among OSAS patients of different races. High-risk populations for OSAS should be highly valued and timely identified for the prevention of VTE, in order to reduce the risk of fatal pulmonary embolism in hospitals.

Key words: Sleep apnea, obstructive, Venous thromboembolism, Pulmonary embolism, Deep vein thrombosis, Meta-analysis

Shanshan Wu, Yumin Pan, Jin Liu, Jinsong Zhang, Li Qiao. Incidence of venous thromboembolism in patients with obstructive sleep apnea syndrome: a meta-analysis[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2024, 17(04): 312-317.

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References 38

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文献	国家及地区	年份	VTE例数	总例数	质量评分（分）
Sweed等^[9]	埃及	2019	40	244	6
Bahar等^[10]	土耳其	2020	4	176	8
Ambrosetti等^[11]	意大利	2004	2	89	7
Lin等^[12]	中国台湾	2013	19	1 424	6
Peng等^[13]	中国台湾	2014	26	3 511	4
Chou等^[14]	中国台湾	2012	30	5 680	4
Seckin等^[15]	美国	2020	75	3 184	4
桂耀松等^[16]	中国	2010	22	2 864	3
肖迪^[17]	中国	2018	13	148	5
Hudgel等^[18]	加拿大	2012	19	1 025	6

文献	国家及地区	年份	VTE例数	总例数	质量评分（分）
Sweed等^[9]	埃及	2019	40	244	6
Bahar等^[10]	土耳其	2020	4	176	8
Ambrosetti等^[11]	意大利	2004	2	89	7
Lin等^[12]	中国台湾	2013	19	1 424	6
Peng等^[13]	中国台湾	2014	26	3 511	4
Chou等^[14]	中国台湾	2012	30	5 680	4
Seckin等^[15]	美国	2020	75	3 184	4
桂耀松等^[16]	中国	2010	22	2 864	3
肖迪^[17]	中国	2018	13	148	5
Hudgel等^[18]	加拿大	2012	19	1 025	6

亚组	文献（篇）	ES（95%CI）	异质性检验结果		Z值	P值
亚组	文献（篇）	ES（95%CI）	I²值（%）	P值	Z值	P值
研究对象来源					6.912	0.021
国内	5	0.011（0.006，0.018）	89.445	<0.001
国外	5	0.040（0.015，0.077）	94.054	<0.001
发表年份					6.912	0.138
2019年前	7	0.012（0.007，0.020）	87.975	<0.001
2019年及以后	3	0.057（0.005，0.155）	-	-
观察结局指标					6.204	0.870
DVT	6	0.016（0.007，0.030）	92.488	<0.001
PE	6	0.015（0.004，0.032）	95.837	<0.001

亚组	文献（篇）	ES（95%CI）	异质性检验结果		Z值	P值
亚组	文献（篇）	ES（95%CI）	I²值（%）	P值	Z值	P值
研究对象来源					6.912	0.021
国内	5	0.011（0.006，0.018）	89.445	<0.001
国外	5	0.040（0.015，0.077）	94.054	<0.001
发表年份					6.912	0.138
2019年前	7	0.012（0.007，0.020）	87.975	<0.001
2019年及以后	3	0.057（0.005，0.155）	-	-
观察结局指标					6.204	0.870
DVT	6	0.016（0.007，0.030）	92.488	<0.001
PE	6	0.015（0.004，0.032）	95.837	<0.001

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