Clinical significance of serum cytokines and fractional exhaled nitric oxide in asthma chronic obstructive pulmonary disease overlap syndrome

doi:10.3877/cma.j.issn.1674-6880.2023.04.009

Abstract

Laqing Chen, Jiajia Lin, Honggang Mao. Clinical significance of serum cytokines and fractional exhaled nitric oxide in asthma chronic obstructive pulmonary disease overlap syndrome[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2023, 16(04): 316-320.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhwzzyxzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-6880.2023.04.009

https://zhwzzyxzz.cma-cmc.com.cn/EN/Y2023/V16/I04/316

Figures/Tables 3

References 26

1	Lane N, Robins RA, Corne J, et al. Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells[J]. Clin Sci (Lond),2010, 119 (2): 75-86.
2	Zhang L, Cheng Z, Liu W, et al. Expression of interleukin (IL)-10, IL-17A and IL-22 in serum and sputum of stable chronic obstructive pulmonary disease patients[J]. COPD, 2013, 10 (4): 459-465.
3	Doe C, Bafadhel M, Siddiqui S, et al. Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD[J]. Chest, 2010, 138 (5): 1140-1147.
4	Pridgeon C, Bugeon L, Donnelly L, et al. Regulation of IL-17 in chronic inflammation in the human lung[J]. Clin Sci (Lond), 2011, 120 (12): 515-524.
5	Kaplanski G. Interleukin-18: biological properties and role in disease pathogenesis[J]. Immunol Rev, 2018, 281 (1): 138-153.
6	Wang J, Liu X, Xie M, et al. Increased expression of interleukin-18 and its receptor in peripheral blood of patients with chronic obstructive pulmonary disease[J]. COPD, 2012, 9 (4): 375-381.
7	Global Initiative for Asthma. Global strategy for asthma management and prevention[R/OL]. 2020[2023-05-06]. URL
8	Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease[R/OL]. 2021[2023-05-06]. URL
9	Barnes PJ. Cellular and molecular mechanisms of asthma and COPD[J]. Clin Sci (Lond), 2017, 131 (13): 1541-1558.
10	de Llano LP, Cosío BG, Iglesias A, et al. Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap: a network approach[J]. Int J Chron Obstruct Pulmon Dis, 2018 (13): 591-601.
11	Gibson PG, Simpson JL. The overlap syndrome of asthma and COPD: what are its features and how important is it?[J]. Thorax, 2009, 64 (8): 728-735.
12	Luzina IG, Lockatell V, Lavania S, et al. Natural production and functional effects of alternatively spliced interleukin-4 protein in asthma[J]. Cytokine, 2012, 58 (1): 20-26.
13	Shen H, Xia L, Lu J. Interleukin-4 in rheumatoid arthritis patients with interstitial lung disease: a pilot study[J]. Indian J Med Res, 2013, 138 (6): 919-921.
14	范致远，冯梦晓，陆远强.轻中度感染性疾病患者进展为脓毒症的相关危险因素分析[J/CD].中华危重症医学杂志（电子版），2022，15（3）：189-197.
15	Heijink IH, Vellenga E, Borger P, et al. Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and independent mechanisms in freshly isolated human T cells[J]. Immunology, 2002, 107 (3): 316-324.
16	何忠，彭玲.急性加重期COPD患者血清TNF-α、IL-6和CRP变化及意义[J].医学临床研究，2008，25（4）：624-625.
17	Dolgachev VA, Yu B, Sun L, et al. Interleukin 10 overexpression alters survival in the setting of gram-negative pneumonia following lung contusion[J]. Shock, 2014, 41 (4): 301-310.
18	Sun L, Cornell TT, LeVine A, et al. Dual role of interleukin-10 in the regulation of respiratory syncitial virus (RSV)-induced lung inflammation[J]. Clin Exp Immunol, 2013, 172 (2): 263-279.
19	Takada E, Furuhata M, Nakae S, et al. Requirement of apoptosis inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin[J]. Int Arch Allergy Immunol, 2013, 162 (2): 104-114.
20	谢晓飞.呼出气一氧化氮、肺功能在慢性阻塞性肺疾病、慢性阻塞性肺疾病合并支气管哮喘综合征之间的差异[D].乌鲁木齐：新疆医科大学，2017.
21	Kudo M, Melton AC, Chen C, et al. IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction[J]. Nat Med, 2012, 18 (4): 547-554.
22	Kubysheva N, Boldina M, Eliseeva T, et al. Relationship of serum levels of IL-17, IL-18, TNF-α, and lung function parameters in patients with COPD, asthma-COPD overlap, and bronchial asthma[J]. Mediators Inflamm, 2020: 4652898.
23	马玉，戴银芳，张新星，等.支气管哮喘患儿呼出一氧化氮水平与外周血中IL-9、IL-17的相关性研究[J].中国实用儿科杂志，2020，35（3）：222-227.
24	Gao Q, Liu Y, Wu Y, et al. IL-17 intensifies IFN-γ induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB[J]. Int J Mol Med, 2016, 37 (2): 347-358.
25	江珍珍，刘夏天，马彩叶，等.白细胞介素18靶向超声微泡对动脉斑块分子成像的实验研究[J/CD].中华危重症医学杂志（电子版），2018，11（2）：100-103.
26	Despotovic M, Stoimenov TJ, Stankovic I, et al. Gene polymorphisms of tumor necrosis factor alpha and antioxidant enzymes in bronchial asthma[J]. Adv Clin Exp Med, 2015, 24 (2): 251-256.

组别	例数	男/女（例）	年龄（岁）	过敏史（例）	吸烟史（例）
BA组	18	10/8	46 ± 21	4	3
COPD组	18	14/4	76 ± 11^a	6	12^a
ACOS组	29	25/4	68 ± 10^a	4	17^a
F/χ²值		5.700	22.153	2.516	10.849
P值		0.058	<0.001	0.284	0.004

组别	例数	男/女（例）	年龄（岁）	过敏史（例）	吸烟史（例）
BA组	18	10/8	46 ± 21	4	3
COPD组	18	14/4	76 ± 11^a	6	12^a
ACOS组	29	25/4	68 ± 10^a	4	17^a
F/χ²值		5.700	22.153	2.516	10.849
P值		0.058	<0.001	0.284	0.004

组别	例数	IgE（× 10³ IU/L）	EOS（× 10⁹/L）	NE（× 10⁹/L）	FeNO（× 10^-9）
BA组	18	250 ± 181^a	0.35 ± 0.20^a	3.6 ± 1.0	49 ± 31^a
COPD组	18	129 ± 78	0.12 ± 0.09	4.7 ± 1.6	23 ± 8
ACOS组	29	238 ± 179^a	0.25 ± 0.24^a	4.1 ± 1.7	36 ± 19^a
F值		3.343	6.186	2.684	6.560
P值		0.042	0.004	0.076	0.003

组别	例数	IgE（× 10³ IU/L）	EOS（× 10⁹/L）	NE（× 10⁹/L）	FeNO（× 10^-9）
BA组	18	250 ± 181^a	0.35 ± 0.20^a	3.6 ± 1.0	49 ± 31^a
COPD组	18	129 ± 78	0.12 ± 0.09	4.7 ± 1.6	23 ± 8
ACOS组	29	238 ± 179^a	0.25 ± 0.24^a	4.1 ± 1.7	36 ± 19^a
F值		3.343	6.186	2.684	6.560
P值		0.042	0.004	0.076	0.003

组别	例数	IL-4	IL-5	IL-6	IL-10	IL-13	IL-17	IL-18	TNF-α
BA组	18	0.663 ± 0.517^a	23 ± 7	6 ± 4^a	1.3 ± 0.8^a	92 ± 13	57 ± 13	469 ± 109	9±4
COPD组	18	0.029 ± 0.016	20 ± 4	11 ± 7	3.4 ± 2.4	83 ± 8	53 ± 8	454 ± 93	11 ± 3
ACOS组	29	0.859 ± 0.815^a	20 ± 7	9±6	2.2 ± 1.5	86 ± 14	59 ± 10	439 ± 109	6 ± 4^ab
F值		10.524	1.258	4.637	2.451	2.375	1.698	0.394	11.554
P值		<0.001	0.291	0.013	0.018	0.101	0.191	0.676	<0.001

Please choose a citation manager

Content to export

Clinical significance of serum cytokines and fractional exhaled nitric oxide in asthma chronic obstructive pulmonary disease overlap syndrome

RichHTML

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

Figures/Tables 3

References 26

Related Articles 0

Recommended Articles

Metrics

Comments

模态框（Modal）标题

Please choose a citation manager

Content to export

Clinical significance of serum cytokines and fractional exhaled nitric oxide in asthma chronic obstructive pulmonary disease overlap syndrome

RichHTML

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

Figures/Tables 3

References 26

Related Articles 0

Recommended Articles

Metrics

Comments