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Chinese Journal of Critical Care Medicine(Electronic Edition) ›› 2022, Vol. 15 ›› Issue (03): 183-188. doi: 10.3877/cma.j.issn.1674-6880.2022.03.002

• Original Article • Previous Articles     Next Articles

Early diagnostic value of two-dimensional speck-tracking echocardiography combined with long non-coding RNA and metastasis associated in lung adenocarcinoma transcript 1 in septic cardiomyopathy

Yuanjie Le1, Weidong Wang1, Zhifei Ben2,()   

  1. 1. Department of Emergency Intensive Care Unit, Ningbo Huamei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China
    2. Department of Ultrasonography, Ningbo Huamei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China
  • Received:2021-09-23 Online:2022-06-30 Published:2022-08-02
  • Contact: Zhifei Ben

Abstract:

Objective

To investigate the diagnostic value of two-dimensional speck-tracking echocardiography (2D-STE) combined with long non-coding RNA (lncRNA) and metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) in septic cardiomyopathy (SCM).

Methods

A total of 86 septic patients admitted to the Department of Emergency Intensive Care Unit of Ningbo Huamei Hospital, University of Chinese Academy of Sciences from January 2019 to January 2021 were selected. According to left ventricular ejection fraction (LVEF), 86 septic patients were divided into a SCM group (LVEF < 50%, n = 37) and a non-SCM group (LVEF ≥ 50%, n = 49). Clinical data, global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS) and serum lncRNA-MALAT1 of the two groups were analyzed. The binary Logistic regression was used to analyze the risk factors affecting the prognosis of patients with SCM, and the receiver operating characteristic (ROC) curve was used to analyze the early diagnostic values of GLS and serum lncRNA-MALAT1 in SCM.

Results

The N-terminal pro-B-type natriuretic peptide (NT-proBNP) [(2 389 ± 2 240) ng/L vs. (1 156 ± 716) ng/L, t = 3.620, P = 0.001], cardiac troponin I (cTnI) [(0.60 ± 0.41) μg/L vs. (0.35 ± 0.29) μg/L, t = 3.301, P = 0.001], GLS [(-18.6 ± 1.6)% vs. (-20.5 ± 2.0)%, t = 4.735, P = 0.001] and lncRNA-MALAT1 [(2.4 ± 0.5) vs. (2.0 ± 0.4), t = 4.219, P = 0.001] all showed significant differences between the SCM group and the non-SCM group. The binary Logistic regression analysis revealed that NT-proBNP [odds ratio (OR) = 0.999, 95% confidence interval (CI) (0.999, 1.000), P = 0.033], cTnI [OR = 0.143, 95%CI (0.024, 0.839), P = 0.031], GLS [OR = 0.543, 95%CI (0.361, 0.817), P = 0.003] and lncRNA-MALAT1 [OR = 0.059, 95%CI (0.011, 0.309), P = 0.001] were independent risk factors for SCM. The ROC curve analysis showed that NT-proBNP [area under the cure (AUC) = 0.697, 95%CI (0.588, 0.791), P = 0.001], cTnI [AUC = 0.681, 95%CI (0.572, 0.778), P = 0.003], GLS[AUC = 0.766, 95%CI (0.667, 0.866), P < 0.001], lncRNA-MALAT1 [AUC = 0.735, 95%CI (0.630, 0.840), P < 0.001] and GLS combined with lncRNA-MALAT1 [AUC = 0.845, 95%CI (0.764, 0.926), P < 0.001] had diagnostic values for SCM. In particular, GLS combined with lncRNA-MALAT1 had the best diagnostic value among these five markers.

Conclusion

The combination detection of 2D-STE and lncRNA-MALAT1 has diagnostic significance on sepsis-induced myocardial injury.

Key words: Septic cardiomyopathy, Long non-coding RNA, Metastasis associated in lung adenocarcinoma transcript 1, Two-dimensional speckle-tracking echocardiography

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