To explore the clinical characteristics and prognosis-related factors in patients with sepsis-induced myocardial injury.

This study enrolled 69 patients with sepsis induced myocardial injury who were treated at the First Affiliated Hospital of Zhejiang University School of Medicine and Quzhou Kecheng District People's Hospital from December 2020 to December 2021. These patients were divided into the survival group (n = 45) and the death group (n = 24) according to the 28-day survival after discharge. The general data, laboratory-related indicators, length of hospital stay and sequential organ failure assessment (SOFA) score between the two groups were compared. The multivariate Logistic regression model was used to identify the independent risk factors for death in patients with sepsis-induced myocardial injury, and the predictive efficacies of relevant indicators for death in patients with sepsis-induced myocardial injury were evaluated by drawing receiver operating characteristic (ROC) curves.

The infection site of patients with sepsis-induced myocardial injury was mainly located at the lungs. The proportions of previous hypertension [62.50% (15/24) vs. 33.33% (15/45), χ² = 5.418, P = 0.024] and chronic lung disease [20.83% (5/24) vs. 4.44% (2/45), χ² = 4.612, P = 0.032], the width of red blood cell distribution[(15.0 ± 1.6)% vs. (14.0 ± 1.5)%, t = 2.426, P = 0.018], SOFA score [(9 ± 4) vs. (6 ± 4), t = 3.457, P = 0.001] and serum interleukin-6 (IL-6) level [763.00 (234.34, 2 656.94) ng/L vs. 94.28 (37.03, 262.98) ng/L, t = 4.158, P < 0.001] at admission in the death group were significantly higher than those in the survival group. However, the body temperature at admission of the patients in the death group was significantly lower than that in the survival group[(37.2 ± 1.2) ℃ vs. (37.8 ± 1.0) ℃, t = 2.312, P = 0.024]. The multivariate Logistic regression analysis revealed that SOFA score, body temperature, serum IL-6 at admission and previous hypertension were all important factors for predicting death in patients with sepsis-induced myocardial injury (all P< 0.05). The ROC curve analysis showed that the combined detection of the above four indicators [area under the cure (AUC) = 0.868, 95% confidence interval (CI) (0.783, 0.952), P < 0.001] and serum IL-6 [AUC = 0.806, 95%CI (0.694, 0.917), P< 0.001] both had good predictive efficacies for death in patients with sepsis-induced myocardial injury.

SOFA score, body temperature, serum IL-6 at admission and previous hypertension can predict the clinical outcomes of patients with sepsis-induced myocardial injury.