Age-related immunosenescence and immunosuppressive network

doi:10.3877/cma.j.issn.1674-6880.2021.01.001

Abstract

Abstract:

With the aggravation of the aging society, the research of age-related immunesenescence has become a new research focus worldwide. Immunesenescence is an important factor leading to the high incidence and mortality of infections, tumors and autoimmune diseases in the elderly. It is closely related to the decline in vaccination efficiency and aging-related diseases such as type 2 diabetes, atherosclerosis, osteoporosis and arthritis. At present, the mechanism of immunesenescence has been explained in the fields of transcriptional regulation, chromatin remodeling, autophagy, ubiquitin-proteasomal system, oxidative stress, and so on. However, immunesenescence is not the irreversible damage and decline of overall immune functions, but the result of long-term adaptive fine adjustment and remodeling of immune system. Evidence has accumulated since the 1970's indicating that immunosenescence might be caused by an increased activity of immunosuppressive cells rather than cellular senescence. Therefore, this article reviews the possible mechanisms of immune aging from the perspectives of the aging-related immune microenvironment changes and activation of immune suppression network.

Key words: Immunosenescence, Inflammaging, Immunosuppressive network, Myeloid derived suppressor cells

Jia Xu, Yuanqiang Lu. Age-related immunosenescence and immunosuppressive network[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2021, 14(01): 3-9.

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