Diagnostic value of plasma soluble triggering receptor expressed on myeloid cells-1 for adult patients with sepsis: a meta-analysis

doi:10.3877/cma.j.issn.1674-6880.2019.05.008

Abstract

Abstract:

Objective

To investigate the diagnostic value of plasma soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a biomarker for adult patients with sepsis.

Methods

Related studies on the diagnostic value of plasma sTREM-1 in adult patients with sepsis were searched in PubMed, Embase, Cochrane, CBM, CNKI, Wangfang and VIP published up to May 2017. The bivariate model was used to calculate the pooled diagnostic odds ratio (DOR), pooled sensitivity, pooled specificity, pooled positive likelihood ratio (PLR), and pooled negative likelihood ratio (NLR). The area under the summary receiver operating characteristic (SROC) curve was analyzed.

Results

Thirty eligible articles involving 3 349 patients were included. Meta-analysis in total population showed that the pooled DOR was 20.03 [95% confidence interval (CI) (12.20, 32.87)]; the pooled sensitivity was 0.82 [95% CI (0.77, 0.86)]; the pooled specificity was 0.81 [95%CI (0.76, 0.85)]; the pooled PLR was 4.36 [95%CI (3.37, 5.64)]; the pooled NLR was 0.22 [95%CI (0.16, 0.29)]. The SROC curve showed that the pooled AUC was 0.89 [95%CI (0.85, 0.91)].

Conclusion

Plasma sTREM-1 has a moderate value in the diagnosis of adult patients with sepsis.

Key words: Soluble triggering receptor expressed on myeloid cells-1, Sepsis, Diagnosis, Meta-analysis

Hongqi Zhang, Huaying Zhao, Chao Yang, Lingwen Kong, Renfu Lu, Qingchen Wu, Dingyuan Du. Diagnostic value of plasma soluble triggering receptor expressed on myeloid cells-1 for adult patients with sepsis: a meta-analysis[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2019, 12(05): 328-334.

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References 43

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文献	国家	样本数（例）	年龄（岁，M或范围）	敏感度（%）	特异度（%）	AUC	真阳性值（例）	假阳性值（例）	假阴性值（例）	真阴性值（例）	质量评分（分）
Latour-Perez等^[7]	西班牙	114	68.6	49.00	79.00	0.620	35	9	37	33	9.5
Giamarellos-Bourboulis等^[8]	希腊	69	51.8	56.50	91.70	0.708	24	2	19	24	11.5
Gibot等^[9]	法国	300	61	53.20	86.30	0.730	82	20	72	126	10.0
郭少卿等^[10]	中国	61	59.8	92.30	86.40	0.932	36	3	3	19	7.5
Brenner等^[11]	德国	90	-	98.30	90.00	0.955	59	3	1	27	10.0
Su等^[12]	中国	130	57.4	91.00	89.60	0.978	91	3	9	27	9.5
Kofoed等^[19]	丹麦	151	56	82.00	40.00	0.610	96	20	21	14	11.5
黄丹^[20]	中国	120	38.1	78.23	52.67	0.920	66	17	18	19	9.5
王涛等^[21]	中国	148	56	86.40	87.50	0.882	64	9	10	65	9.0
曾小莉等^[22]	中国	108	55.6	79.00	70.00	0.722	54	12	14	28	10.0
Song等^[23]	中国	128	65.9	80.00	76.00	0.820	54	14	14	46	10.5
Gamez-Diaz等^[24]	哥伦比亚	616	51	60.00	59.20	0.614	243	86	162	125	10.5
罗运山等^[25]	中国	66	71.6	84.60	86.70	0.877	33	4	6	23	6.5
余娇等^[26]	中国	69	18 ~ 60	83.30	77.80	0.819	19	10	4	36	10.0
茅尧生等^[27]	中国	74	42.62	85.50	82.70	0.874	50	3	9	12	12.0
梁杰昌等^[28]	中国	93	62.6	86.00	91.00	0.933	43	4	7	39	9.5
杨俊杰等^[29]	中国	70	59.8	78.90	82.10	0.796	31	6	8	25	11.5
梁微波等^[30]	中国	58	64.5	80.00	83.33	0.820	32	3	8	15	8.5
陈兴旺等^[31]	中国	84	57.4	87.40	84.60	0.894	49	4	7	24	10.5
张羿等^[32]	中国	55	50.6	74.00	70.00	0.750	26	6	9	14	8.0
茅尧生等^[33]	中国	65	40.76	77.60	80.30	0.842	38	3	11	13	11.5
董裕康等^[34]	中国	64	58	76.70	90.50	0.868	33	2	10	19	12.0
Aksaray等^[35]	土耳其	90	64.27	71.15	76.32	0.780	37	9	15	29	10.5
Halim等^[36]	土耳其	74	50.3	81.80	73.20	0.826	27	11	6	30	11.0
Li等^[37]	中国	52	55.6	79.00	79.00	0.820	30	3	8	11	10.5
Wang等^[38]	中国	56	63.8	93.80	84.70	0.935	30	4	2	20	10.5
Soud等^[39]	埃及	80	30.5	94.70	91.80	-	18	5	1	56	9.0
Barati等^[40]	伊朗	95	58.2	70.00	60.00	0.650	36	17	16	26	10.5
Rivera-Chavez等^[41]	美国	93	34.8	96.00	91.00	0.970	54	3	2	34	11.0
Gibot等^[42]	法国	76	60	96.00	89.00	0.970	45	3	2	26	12.5

文献	国家	样本数（例）	年龄（岁，M或范围）	敏感度（%）	特异度（%）	AUC	真阳性值（例）	假阳性值（例）	假阴性值（例）	真阴性值（例）	质量评分（分）
Latour-Perez等^[7]	西班牙	114	68.6	49.00	79.00	0.620	35	9	37	33	9.5
Giamarellos-Bourboulis等^[8]	希腊	69	51.8	56.50	91.70	0.708	24	2	19	24	11.5
Gibot等^[9]	法国	300	61	53.20	86.30	0.730	82	20	72	126	10.0
郭少卿等^[10]	中国	61	59.8	92.30	86.40	0.932	36	3	3	19	7.5
Brenner等^[11]	德国	90	-	98.30	90.00	0.955	59	3	1	27	10.0
Su等^[12]	中国	130	57.4	91.00	89.60	0.978	91	3	9	27	9.5
Kofoed等^[19]	丹麦	151	56	82.00	40.00	0.610	96	20	21	14	11.5
黄丹^[20]	中国	120	38.1	78.23	52.67	0.920	66	17	18	19	9.5
王涛等^[21]	中国	148	56	86.40	87.50	0.882	64	9	10	65	9.0
曾小莉等^[22]	中国	108	55.6	79.00	70.00	0.722	54	12	14	28	10.0
Song等^[23]	中国	128	65.9	80.00	76.00	0.820	54	14	14	46	10.5
Gamez-Diaz等^[24]	哥伦比亚	616	51	60.00	59.20	0.614	243	86	162	125	10.5
罗运山等^[25]	中国	66	71.6	84.60	86.70	0.877	33	4	6	23	6.5
余娇等^[26]	中国	69	18 ~ 60	83.30	77.80	0.819	19	10	4	36	10.0
茅尧生等^[27]	中国	74	42.62	85.50	82.70	0.874	50	3	9	12	12.0
梁杰昌等^[28]	中国	93	62.6	86.00	91.00	0.933	43	4	7	39	9.5
杨俊杰等^[29]	中国	70	59.8	78.90	82.10	0.796	31	6	8	25	11.5
梁微波等^[30]	中国	58	64.5	80.00	83.33	0.820	32	3	8	15	8.5
陈兴旺等^[31]	中国	84	57.4	87.40	84.60	0.894	49	4	7	24	10.5
张羿等^[32]	中国	55	50.6	74.00	70.00	0.750	26	6	9	14	8.0
茅尧生等^[33]	中国	65	40.76	77.60	80.30	0.842	38	3	11	13	11.5
董裕康等^[34]	中国	64	58	76.70	90.50	0.868	33	2	10	19	12.0
Aksaray等^[35]	土耳其	90	64.27	71.15	76.32	0.780	37	9	15	29	10.5
Halim等^[36]	土耳其	74	50.3	81.80	73.20	0.826	27	11	6	30	11.0
Li等^[37]	中国	52	55.6	79.00	79.00	0.820	30	3	8	11	10.5
Wang等^[38]	中国	56	63.8	93.80	84.70	0.935	30	4	2	20	10.5
Soud等^[39]	埃及	80	30.5	94.70	91.80	-	18	5	1	56	9.0
Barati等^[40]	伊朗	95	58.2	70.00	60.00	0.650	36	17	16	26	10.5
Rivera-Chavez等^[41]	美国	93	34.8	96.00	91.00	0.970	54	3	2	34	11.0
Gibot等^[42]	法国	76	60	96.00	89.00	0.970	45	3	2	26	12.5

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