Relationship between serum cardiac ankyrin repeat protein and hypersensitive C-reactive protein, creatine kinase isoenzyme MB, and cardiac troponin I in patients with acute ST elevation myocardial infarction

doi:10.3877/cma.j.issn.1674-6880.2017.02.003

Abstract

Abstract:

Objective

To explore the relationship between serum cardiac ankyrin repeat protein (CARP) and hypersensitive C-reactive protein (hs-CRP), creatine kinase isoenzyme MB (CK-MB), and cardiac troponin I (cTn-I) in patients with acute ST elevation myocardial infarction (STEMI).

Methods

A total of 60 acute STEMI patients were enrolled in this study. Levels of hs-CRP, CK-MB, cTn-I and CARP were detected at ≤ 6 h, > 6~12 h, > 12~24 h, 72 h after heart attack. The Pearson correlation analysis was used to analyze the relationship between the CARP levels in each period and hs-CRP, CK-MB, cTn-I.

Results

The levels of hs-CRP, CK-MB, cTnI, CARP were significantly different at each period (F = 487.534, 683.673, 666.447, 1121.437, all P < 0.05). Hs-CRP at > 12~24 h and 72 h were much higher than those at ≤ 6 h and > 6~12 h [(29 ± 26), (43 ± 28), (8 ± 7), (8 ± 7)mg/L, all P < 0.05]. CK-MB showed significant differences at ≤ 6 h, > 6~12 h, > 12~24 h, 72 h [(40 ± 16), (124 ± 53), (374 ± 98), (108 ± 40) μg/L, all P < 0.05]. cTnI at > 6~12 h, > 12~24 h, and 72 h were much higher than those at ≤ 6 h after heart attack [(7.3 ± 3.4), (10.3 ± 5.3), (6.5 ± 3.5), (3.6 ± 2.4) μg/L, all P < 0.05]. CARP only at > 12~24 h increased markedly as compared at ≤ 6 h, > 6~12 h, 72 h after heart attack [(1 991 ± 538), (1 391 ± 471), (1 385 ± 407), (1 347 ± 429) kU/L, all P < 0.05]. The Pearson revealed that the CARP levels at each period were positively correlated with CK-MB.

Conclusion

CARP increased obviously in STEMI patients and can be used as a new indicator for the diagnosis of STEMI.

Key words: Acute ST elevation myocardial infarction, Cardiac ankyrin repeat protein, Hypersensitive C-reactive protein, Creatine kinase, MB form, Troponin I

Fuwei Zhang, Qian Xie, Moshui Chen, Yixue Zhang, Liangqiang Ren, bo Xing, Dayan Li. Relationship between serum cardiac ankyrin repeat protein and hypersensitive C-reactive protein, creatine kinase isoenzyme MB, and cardiac troponin I in patients with acute ST elevation myocardial infarction[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2017, 10(02): 82-86.

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References 20

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时间段	hs-CRP（mg/L）	CK-MB（μg/L）	cTnI（μg/L）	CARP（kU/L）
≤6h	8±7	40 ± 16	1391 ± 471	1 391 ± 471
>6 ~ 12 h	8±7	124 ± 53^a	7.3 ± 3.4^a	1 385 ± 407
>6 ~ 12 h	29 ± 26^ab	374 ± 98^ab	10.3 ± 5.3^ab	1 991 ± 538^ab
72 h	43 ± 28^abc	108 ± 40^abc	6.5 ± 3.5^ac	1 347 ± 429^c
F值	487.534	683.673	666.447	1121.437
P值	0.002	< 0.001	< 0.001	< 0.001

时间段	hs-CRP（mg/L）	CK-MB（μg/L）	cTnI（μg/L）	CARP（kU/L）
≤6h	8±7	40 ± 16	1391 ± 471	1 391 ± 471
>6 ~ 12 h	8±7	124 ± 53^a	7.3 ± 3.4^a	1 385 ± 407
>6 ~ 12 h	29 ± 26^ab	374 ± 98^ab	10.3 ± 5.3^ab	1 991 ± 538^ab
72 h	43 ± 28^abc	108 ± 40^abc	6.5 ± 3.5^ac	1 347 ± 429^c
F值	487.534	683.673	666.447	1121.437
P值	0.002	< 0.001	< 0.001	< 0.001

时段	hs-CRP		CK-MB		cTnI
时段	r值	P值	r值	P值	r值	P值
≤6h	0.037	0.777	0.753	< 0.001	-0.106	0.424
>6 ~ 12 h	0.032	0.763	0.787	< 0.001	-0.071	0.592
>12 ~ 24 h	0.023	0.862	0.347	0.002	-0.119	0.380
72 h	-0.071	0.602	0.567	< 0.001	-0.115	0.381

时段	hs-CRP		CK-MB		cTnI
时段	r值	P值	r值	P值	r值	P值
≤6h	0.037	0.777	0.753	< 0.001	-0.106	0.424
>6 ~ 12 h	0.032	0.763	0.787	< 0.001	-0.071	0.592
>12 ~ 24 h	0.023	0.862	0.347	0.002	-0.119	0.380
72 h	-0.071	0.602	0.567	< 0.001	-0.115	0.381

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