Multivariate analysis of Vitamin K1 maintenance dose in patients with anticoagulant rodenticide poisoning

doi:10.3877/cma.j.issn.1674-6880.2016.02.003

Abstract

Abstract:

Objective

To investigate the effect factors of Vitamin K1 maintenance dose in patients with anticoagulant rodenticide poisoning.

Methods

This retrospective study was analyzed 36 cases in our hospital from January 2013 to October 2014. The correlation between Vitamin K1 and types of anticoagulant rodenticide and toxic dose, prothrombin time activity (PTA), prothrombin time (PT), activated partial thromboplastin time (APTT), prehospital duration (from poisoning to hospitalization), and length of hospital stay (duration of Vitamin K1 treatment) were collected and analyzed by Spearman rank correlation analysis and multivariate regression analysis.

Results

The dose of Vitamin K1 was positively correlated with brodifacoum (r=0.356, P<0.05), negative correlated with PTA, prehospital duration and length of hospital stay (r=-0.325, -0.420, -0.407, all P<0.05). However, there were no significant correlation between dose of Vitamin K1 and PT, APTT, bromadiolone (r=0.295, -0.312, 0.192, all P>0.05). The multivariate regression analysis also showed that prehospital duration [95% confidence interval: (-0.536, -0.103), P=0.002] and length of hospital stay [95% confidence interval: (-1.955, -0.248), P=0.013] had significant effect on the maintenance dose of vitamin K1 in the patients with coagulation function stable.

Conclusion

After stabilizing the coagulation function, the demanded maintenance dose of vitamin K1 can be gradually decreased with time prolonged, and have no relationship with type of anticoagulant rodenticide and toxic dose.

Key words: Anticoagulant rodenticide, Poisoning, Vitamin K1, Multivariate analysis

Jianhai Long, Yawei Sun, Zewu Qiu. Multivariate analysis of Vitamin K1 maintenance dose in patients with anticoagulant rodenticide poisoning[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2016, 09(02): 87-90.

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References 20

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因素	偏回归系数	标准误	检验值	P值	95%置信区间
溴鼠灵（mg/L）	-0.004	0.010	0.45	0.653	-0.024 ~ 0.016
凝血酶原活动度（%）	-0.190	0.300	0.63	0.532	-0.801 ~ 0.422
院前时间（d）	-0.319	0.106	3.01	0.005	-0.536 ~ -0.103
住院时间（d）	-1.102	0.419	2.63	0.013	-1.955 ~ -0.248
常数项（mg）	103.165	25.640	4.02	0.000	50.937 ~ 155.393

因素	偏回归系数	标准误	检验值	P值	95%置信区间
溴鼠灵（mg/L）	-0.004	0.010	0.45	0.653	-0.024 ~ 0.016
凝血酶原活动度（%）	-0.190	0.300	0.63	0.532	-0.801 ~ 0.422
院前时间（d）	-0.319	0.106	3.01	0.005	-0.536 ~ -0.103
住院时间（d）	-1.102	0.419	2.63	0.013	-1.955 ~ -0.248
常数项（mg）	103.165	25.640	4.02	0.000	50.937 ~ 155.393

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