Effect of statins on in-hospital mortality in elderly Chinese patients with sepsis: a retrospective cohort study

doi:10.3877/cma.j.issn.1674-6880.2016.01.006

Abstract

Abstract:

Objective

To investigate the prognostic value of statins on elderly Chinese patients with sepsis.

Methods

A total of 212 elderly Chinese patients with sepsis hospitalized in First Affiliated Hospital, Zhejiang University School of Medicine, from March 2009 to March 2012 were enrolled into the study. Time to discharge from the hospital was selected as the primary endpoint. All the patients were divided into the death group and survival group, and the variables were compared between the two groups. The multivariate logistic regression was applied to assess the independent risk factors for death among the patients during the hospitalization.

Results

The proportion of the patients treated by statins continuously in the death group was significantly higher than that in the survival group [13.9% (5/36) vs. 34.7% (61/176), χ² = 6.014, P = 0.014], and the statins were the independent predictor for death during hospitalization (OR: 0.17; 95%CI: 0.04 - 0.85; P = 0.03).

Conclusion

Statins may reduce the in-hospital mortality in elderly Chinese patients with sepsis.

Key words: Sepsis, Elderly, Statins, In-hospital mortality

Qifeng Gui, Yunmei Yang, Jiajia Zhang. Effect of statins on in-hospital mortality in elderly Chinese patients with sepsis: a retrospective cohort study[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2016, 09(01): 34-37.

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References 20

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组别	例数	年龄（岁）	男性[例(%)]	吸烟[例(%)]	饮酒[例(%)]	APACHEⅡ评分（分）	需激素治疗[例(%)]	他汀使用[例(%)]	血培养阳性[例(%)]	院内感染[例(%)]
死亡组	36	82 ± 5	28(77.8)	1(2.8)	2(5.6)	17.1 ± 4.6	26(72.2)	5(13.9)	9(25)	17(47.2)
存活组	176	82 ± 6	132(75)	22(12.5)	8(4.5)	10.7 ± 4.4	26(14.8)	61(34.7)	21(11.9)	61(34.7)
χ²/t/Z值	?	0.601	0.125	-	-	6.930	53.284	6.014	4.021	2.028
P值	?	0.548	0.724	0.137	0.799	< 0.001	< 0.001	0.014	0.040	0.154
组别	例数	院前抗生素[例(%)]	转入ICU[例(%)]	严重脓毒症[例(%)]	白蛋白(g/L)	C反应蛋白(mg/L)	合并症[例(%)]
组别	例数	院前抗生素[例(%)]	转入ICU[例(%)]	严重脓毒症[例(%)]	白蛋白(g/L)	C反应蛋白(mg/L)	慢性阻塞性肺病	高血压	2型糖尿病
死亡组	36	25(69.4)	23(63.9)	30(83.3)	32 ± 4	47.1(17.2,89.4)	15(41.7)	27(75)	11(30.6)
存活组	176	87(49.4)	11(6.3)	26(14.8)	37 ± 5	34.8(11.8,71.1)	47(26.7)	117(66.5)	60(34.1)
χ²/t/Z值	?	4.803	73.737	72.275	5.175	0.640	3.233	0.996	0.168
P值	?	0.028	< 0.001	< 0.001	< 0.001	0.522	0.072	0.318	0.682
组别	例数	合并症[例(%)]
组别	例数	恶性肿瘤	缺血性心脏病	脑血管疾病	慢性肾衰竭	慢性心力衰竭	慢性肝脏疾病	外周血管疾病
死亡组	36	14(38.9)	14(38.9)	7(19.4)	3(8.3)	12(33.3)	2(5.5)	2(5.5)
存活组	176	26(14.8)	54(30.7)	38(21.6)	12(6.8)	19(10.8)	7(4.0)	8(22.2)
χ²/t/Z值	?	11.355	0.924	0.082	-	12.16	-	-
P值	?	0.001	0.336	0.774	0.752	< 0.001	0.679	0.679

组别	例数	年龄（岁）	男性[例(%)]	吸烟[例(%)]	饮酒[例(%)]	APACHEⅡ评分（分）	需激素治疗[例(%)]	他汀使用[例(%)]	血培养阳性[例(%)]	院内感染[例(%)]
死亡组	36	82 ± 5	28(77.8)	1(2.8)	2(5.6)	17.1 ± 4.6	26(72.2)	5(13.9)	9(25)	17(47.2)
存活组	176	82 ± 6	132(75)	22(12.5)	8(4.5)	10.7 ± 4.4	26(14.8)	61(34.7)	21(11.9)	61(34.7)
χ²/t/Z值	?	0.601	0.125	-	-	6.930	53.284	6.014	4.021	2.028
P值	?	0.548	0.724	0.137	0.799	< 0.001	< 0.001	0.014	0.040	0.154
组别	例数	院前抗生素[例(%)]	转入ICU[例(%)]	严重脓毒症[例(%)]	白蛋白(g/L)	C反应蛋白(mg/L)	合并症[例(%)]
组别	例数	院前抗生素[例(%)]	转入ICU[例(%)]	严重脓毒症[例(%)]	白蛋白(g/L)	C反应蛋白(mg/L)	慢性阻塞性肺病	高血压	2型糖尿病
死亡组	36	25(69.4)	23(63.9)	30(83.3)	32 ± 4	47.1(17.2,89.4)	15(41.7)	27(75)	11(30.6)
存活组	176	87(49.4)	11(6.3)	26(14.8)	37 ± 5	34.8(11.8,71.1)	47(26.7)	117(66.5)	60(34.1)
χ²/t/Z值	?	4.803	73.737	72.275	5.175	0.640	3.233	0.996	0.168
P值	?	0.028	< 0.001	< 0.001	< 0.001	0.522	0.072	0.318	0.682
组别	例数	合并症[例(%)]
组别	例数	恶性肿瘤	缺血性心脏病	脑血管疾病	慢性肾衰竭	慢性心力衰竭	慢性肝脏疾病	外周血管疾病
死亡组	36	14(38.9)	14(38.9)	7(19.4)	3(8.3)	12(33.3)	2(5.5)	2(5.5)
存活组	176	26(14.8)	54(30.7)	38(21.6)	12(6.8)	19(10.8)	7(4.0)	8(22.2)
χ²/t/Z值	?	11.355	0.924	0.082	-	12.16	-	-
P值	?	0.001	0.336	0.774	0.752	< 0.001	0.679	0.679

独立预测因子	偏回归系数	标准误	wald值	OR(95%CI)值	P值
他汀使用	-1.748	0.807	4.695	0.17(0.04 ~ 0.85)	0.030
需激素治疗	1.799	0.670	7.211	6.04(1.63 ~ 22.45)	0.007
严重脓毒症	2.540	0.677	14.068	12.68(3.36 ~ 47.80)	< 0.001
恶性肿瘤	2.637	0.742	12.615	13.97(3.26 ~ 59.84)	< 0.001
转入ICU	2.097	0.796	6.941	8.14(1.71 ~ 38.72)	0.008

独立预测因子	偏回归系数	标准误	wald值	OR(95%CI)值	P值
他汀使用	-1.748	0.807	4.695	0.17(0.04 ~ 0.85)	0.030
需激素治疗	1.799	0.670	7.211	6.04(1.63 ~ 22.45)	0.007
严重脓毒症	2.540	0.677	14.068	12.68(3.36 ~ 47.80)	< 0.001
恶性肿瘤	2.637	0.742	12.615	13.97(3.26 ~ 59.84)	< 0.001
转入ICU	2.097	0.796	6.941	8.14(1.71 ~ 38.72)	0.008

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