切换至 "中华医学电子期刊资源库"

中华危重症医学杂志(电子版) ›› 2025, Vol. 18 ›› Issue (06) : 502 -508. doi: 10.3877/cma.j.issn.1674-6880.2025.06.011

综述

脓毒症中血小板及其去唾液酸化的研究进展
陈韵竺, 彭玥()   
  1. 410000 长沙,中南大学湘雅三医院重症医学科
  • 收稿日期:2025-06-02 出版日期:2025-12-31
  • 通信作者: 彭玥
  • 基金资助:
    湖南省重点研发计划项目(2023SK2035)
  • Received:2025-06-02 Published:2025-12-31
引用本文:

陈韵竺, 彭玥. 脓毒症中血小板及其去唾液酸化的研究进展[J/OL]. 中华危重症医学杂志(电子版), 2025, 18(06): 502-508.

1
Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study[J]. Lancet, 2020, 395 (10219): 200-211.
2
Rhee C, Jones TM, Hamad Y, et al. Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals[J]. JAMA Netw Open, 2019, 2 (2): e187571.
3
闵婕,陆建红,姬晓伟,等.血小板与淋巴细胞比值对脓毒症患者预后的评估价值[J].浙江医学202244(21):2256-2259,2264.
4
de Stoppelaar SF, van't Veer C, van der Poll T. The role of platelets in sepsis[J]. Thromb Haemost, 2014, 112 (4): 666-677.
5
Guidotti LG, Inverso D, Sironi L, et al. Immunosurveillance of the liver by intravascular effector CD8+ T cells[J]. Cell, 2015, 161 (3): 486-500.
6
Mandel J, Casari M, Stepanyan M, et al. Beyond hemostasis: platelet innate immune interactions and thromboinflammation[J]. Int J Mol Sci, 2022, 23 (7): 3868.
7
Colón DF, Wanderley CW, Franchin M, et al. Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis[J]. Crit Care, 2019, 23 (1): 113.
8
Martins PADC, van Gils JM, Mol A, et al. Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of β1 and β2 integrins[J]. J Leukoc Biol, 2006, 79 (3): 499-507.
9
Fricke I, Mitchell D, Petersen F, et al. Platelet factor 4 in conjunction with IL-4 directs differentiation of human monocytes into specialized antigen-presenting cells[J]. FASEB J, 2004, 18 (13): 1588-1590.
10
Li C, Li J, Ni H. Crosstalk between platelets and microbial pathogens[J]. Front Immunol, 2020, 11: 1962.
11
Guo L, Shen S, Rowley JW, et al. Platelet MHC class I mediates CD8+ T-cell suppression during sepsis[J]. Blood, 2021, 138 (5): 401-416.
12
全军重症医学专业委员会,中华医学会检验医学分会.中国成人重症患者血小板减少诊疗专家共识[J].解放军医学杂志45(5):457-474.
13
Menard CE, Kumar A, Houston DS, et al. Evolution and impact of thrombocytopenia in septic shock: a retrospective cohort study[J]. Crit Care Med, 2019, 47 (4): 558-565.
14
Claushuis TA, van Vught LA, Scicluna BP, et al. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients[J]. Blood, 2016, 127 (24): 3062-3072.
15
Azkárate I, Choperena G, Salas E, et al. Epidemiology and prognostic factors in severe sepsis/septic shock. Evolution over six years[J]. Med Intensiva, 2016, 40 (1): 18-25.
16
贾亚娟,蒙钰铭,高志伟,等.血小板与淋巴细胞比值、降钙素原和白细胞介素6联合检测对脓毒症患者预后价值的研究[J/OL].中华危重症医学杂志(电子版)202417(2):118-123.
17
Jenne CN. Platelets: crossroads of immunity and hemostasis[J]. Blood, 2014, 124 (5): 671-672.
18
Cines DB, Bussel JB, Liebman HA, et al. The ITP syndrome: pathogenic and clinical diversity[J]. Blood, 2009, 113 (26): 6511-6521.
19
Li MF, Li XL, Fan KL, et al. Platelet desialylation is a novel mechanism and a therapeutic target in thrombocytopenia during sepsis: an open-label, multicenter, randomized controlled trial[J]. J Hematol Oncol, 2017, 10 (1): 104.
20
Andonegui G, Kerfoot SM, McNagny K, et al. Platelets express functional Toll-like receptor-4[J]. Blood, 2005, 106 (7): 2417-2423.
21
Kaser A, Brandacher G, Steurer W, et al. Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis[J]. Blood, 2001, 98 (9): 2720-2725.
22
Paulson JC, Coiley KJ. Glycosyltransferases. Structure, localization, and control of cell type-specific glycosylation[J]. J Biol Chem, 1989, 264 (30): 17615-17618.
23
Miyagi T, Wada T, Yamaguchi K, et al. Sialidase and malignancy: a minireview[J]. Glycoconj J, 2004, 20 (3): 189-198.
24
Suzuki Y. Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses[J]. Biol Pharm Bull, 2005, 28 (3): 399-408.
25
Sorensen AL, Rumjantseva V, Nayeb-Hashemi S, et al. Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes[J]. Blood, 2009, 114 (8): 1645-1654.
26
Grewal PK, Uchiyama S, Ditto D, et al. The Ashwell receptor mitigates the lethal coagulopathy of sepsis[J]. Nat Med, 2008, 14 (6): 648-655.
27
Li J, van der Wal DE, Zhu G, et al. Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia[J]. Nat Commun, 2015, 6: 7737.
28
Grewal PK. The Ashwell-Morell receptor[J]. Methods Enzymol, 2010, 479: 223-241.
29
Grewal PK, Aziz PV, Uchiyama S, et al. Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor[J]. Proc Natl Acad Sci U S A, 2013, 110 (50): 20218-20223.
30
Deppermann C, Kratofil RM, Peiseler M, et al. Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets[J]. J Exp Med, 2020, 217 (4): e20190723.
31
Taylor ME, Snelling T, Smith DF, et al. Absence of a human ortholog of rodent Kupffer cell galactose-binding receptor encoded by the CLEC4f gene[J]. Glycobiology, 2019, 29 (4): 332-345.
32
Jiang Y, Tang Y, Hoover C, et al. Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice[J]. Cell Death Differ, 2021, 28 (11): 3009-3021.
33
Bosmann HB. Platelet adhesiveness and aggregation. Ⅱ. Surface sialic acid, glycoprotein: N-acetylneuraminic acid transferase, and neuraminidase of human blood platelets[J]. Biochim Biophys Acta, 1972, 279 (3): 456-474.
34
Choi SI, Simone JV, Journey LJ. Neuraminidase-induced thrombocytopenia in rats[J]. Br J Haematol, 1972, 22 (1): 93-101.
35
Greenberg J, Packham MA, Cazenave JP, et al. Effects on platelet function of removal of platelet sialic acid by neuraminidase[J]. Lab Invest, 1975, 32 (4): 476-484.
36
Grozovsky R, Begonja AJ, Liu K, et al. The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling[J]. Nat Med, 2015, 21 (1): 47-54.
37
Murphy S, Gardner FH. Platelet preservation: effect of storage temperature on maintenance of platelet viability-deleterious effect of refrigerated storage[J]. N Engl J Med, 1969, 280 (20): 1094-1098.
38
Jansen AJ, Peng J, Zhao HG, et al. Sialidase inhibition to increase platelet counts: a new treatment option for thrombocytopenia[J]. Am J Hematol, 2015, 90 (5): E94-E95.
39
Bigot P, Auffret M, Gautier S, et al. Unexpected platelets elevation in a patient with idiopathic thrombocytopenia treated with oseltamivir for influenza infection[J]. Fundam Clin Pharmacol, 2016, 30 (5): 483-485.
40
Quach ME, Chen W, Li R. Mechanisms of platelet clearance and translation to improve platelet storage[J]. Blood, 2018, 131 (14): 1512-1521.
41
Zheng SS, Ahmadi Z, Leung HHL, et al. Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia[J]. Haematologica, 2022, 107 (9): 2195-2205.
42
Cognasse F, Nguyen KA, Damien P, et al. The inflammatory role of platelets via their TLRs and siglec receptors[J]. Front Immunol, 2015, 6: 83.
43
Voos KM, Cao W, Arce NA, et al. Desialylation of O-glycans activates von Willebrand factor by destabilizing its autoinhibitory module[J]. J Thromb Haemost, 2022, 20 (1): 196-207.
44
Jeong SH, Park JY, Ryu YB, et al. Myristica fragrans extract inhibits platelet desialylation and activation to ameliorate sepsis-associated thrombocytopenia in a murine CLP-induced sepsis model[J]. Int J Mol Sci, 2023, 24 (10): 8863.
45
Hinek A, Bodnaruk TD, Bunda S, et al. Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2[J]. Am J Pathol, 2008, 173 (4): 1042-1056.
46
Grozovsky R, Fraser CS, Hoffmeister KM, et al. Desialylation and apoptosis crosstalk to modulate platelet clearance[J]. Blood, 2019, 134 (Supplement_1): 1055.
47
Qiu J, Liu X, Li X, et al. CD8+ T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia[J]. Sci Rep, 2016, 6: 27445.
48
Chen Y, Luo L, Zheng Y, et al. Association of platelet desialylation and circulating follicular helper T cells in patients with thrombocytopenia[J]. Front Immunol, 2022, 13: 810620.
49
Li J, Karakas D, Xue F, et al. Desialylated platelet clearance in the liver is a novel mechanism of systemic immunosuppression[J]. Research (Wash D C), 2023, 6: 0236.
50
Cao Y, Ma W, Liu Z, et al. Early predictive value of platelet function for clinical outcome in sepsis[J]. J Infect, 2022, 84 (5): 628-636.
51
Mandic R, Opper C, Krappe J, et al. Platelet sialic acid as a potential pathogenic factor incoronary heart disease[J]. Thromb Res, 2002, 106: 137-141.
52
Hyvarinen S, Meri S, Jokiranta TS. Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome[J]. Blood, 2016, 127 (22): 2701-2710.
53
Kullaya V, de Jonge MI, Langereis JD, et al. Desialylation of platelets by pneumococcal neuraminidase A induces ADP-dependent platelet hyperreactivity[J]. Infect Immun, 2018, 86 (10): e00213-e00218.
54
Marini I, Zlamal J, Faul C, et al. Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan[J]. Haematologica, 2021, 106 (1): 196-207.
No related articles found!
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?