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中华危重症医学杂志(电子版) ›› 2025, Vol. 18 ›› Issue (06) : 496 -501. doi: 10.3877/cma.j.issn.1674-6880.2025.06.010

综述

血必净治疗脓毒症相关急性呼吸窘迫综合征的研究进展
王学文1, 张龙琪1, 杨军芬1,2, 陈明明1,2, 文自立1, 杜抒蓉1, 朱磊1,2,()   
  1. 1730000 兰州,兰州大学第一临床医学院
    2730000 兰州,兰州大学第一医院重症医学科
  • 收稿日期:2025-06-02 出版日期:2025-12-31
  • 通信作者: 朱磊
  • 基金资助:
    甘肃省高等学校创新基金项目(2021B-022); 2024年兰州大学学生创新创业行动计划项目(20240060011)
  • Received:2025-06-02 Published:2025-12-31
引用本文:

王学文, 张龙琪, 杨军芬, 陈明明, 文自立, 杜抒蓉, 朱磊. 血必净治疗脓毒症相关急性呼吸窘迫综合征的研究进展[J/OL]. 中华危重症医学杂志(电子版), 2025, 18(06): 496-501.

1
Fernando SM, Ferreyro BL, Urner M, et al. Diagnostic et traitement du syndrome de détresse respiratoire aigu?[J]. CMAJ, 2021, 193 (25): E978-E986. (in French).
2
郑永信,桑岭,黎毅敏.脓毒症相关急性呼吸窘迫综合征的研究进展[J].临床内科杂志202138(9):580-583.
3
Gong H, Chen Y, Chen M, et al. Advanced development and mechanism of sepsis-related acute respiratory distress syndrome[J]. Front Med (Lausanne), 2022, 9: 1043859.
4
Fernando SM, Ferreyro BL, Urner M, et al. Diagnosis and management of acute respiratory distress syndrome[J]. CMAJ, 2021, 193 (21): E761-E768.
5
Iba T, Levy JH. Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis[J]. J Thromb Haemost, 2018, 16 (2): 231-241.
6
Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018[J]. Cell Death Differ, 2018, 25 (3): 486-541.
7
Guo R, Li Y, Han M, et al. Emodin attenuates acute lung injury in cecal-ligation and puncture rats[J]. Int Immunopharmacol, 2020, 85: 106626.
8
Liu C, Xiao K, Xie L. Advances in the use of exosomes for the treatment of ALI/ARDS[J]. Front Immunol, 2022, 13: 971189.
9
Gong P, Lu Z, Xing J, et al. Traditional Chinese medicine Xuebijing treatment is associated with decreased mortality risk of patients with moderate paraquat poisoning[J]. PLoS One, 2015, 10 (4): e0123504.
10
Li C, Wang P, Zhang L, et al. Efficacy and safety of Xuebijing injection (a Chinese patent) for sepsis: a meta-analysis of randomized controlled trials[J]. J Ethnopharmacol, 2018, 224: 512-521.
11
Gao W, Li N, Cui XG. Efficacy of Xuebijing injection (血必净注射液) on cardiopulmonary bypass-associated pulmonary injury: a prospective, single-center, randomized, double blinded trial[J]. Chin J Integr Med, 2018, 24 (11): 815-821.
12
Wang H, Bloom O, Zhang M, et al. HMG-1 as a late mediator of endotoxin lethality in mice[J]. Science, 1999, 285 (5425): 248-251.
13
沈沛,何国丽,徐娜娜,等.脓毒症相关性急性肺损伤信号通路的研究进展[J/OL].中华危重症医学杂志(电子版)202417(4):326-330.
14
Young MD, Cancio TS, Thorpe CR, et al. Circulatory HMGB1 is an early predictive and prognostic biomarker of ARDS and mortality in a swine model of polytrauma[J]. Front Immunol, 2023, 14: 1227751.
15
Tang D, Kang R, Xiao W, et al. Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function[J]. Am J Respir Cell Mol Biol, 2009, 41 (6): 651-660.
16
Chen S, Dai G, Hu J, et al. Discovery of Xuebijing injection exhibiting protective efficacy on sepsis by inhibiting the expression of HMGB1 in septic rat model designed by cecal ligation and puncture[J]. Am J Ther, 2016, 23 (6): e1819-e1825.
17
Xia P, Wu Y, Lian S, et al. Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses[J]. Appl Microbiol Biotechnol, 2021, 105 (13): 5341-5355.
18
Han JM, Lee EK, Gong SY, et al. Sparassis crispa exerts anti-inflammatory activity via suppression of TLR-mediated NF-κB and MAPK signaling pathways in LPS-induced RAW264.7 macrophage cells[J]. J Ethnopharmacol, 2019, 231: 10-18.
19
Karimi A, Naeini F, Asghari Azar V, et al. A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis[J]. Phytomedicine, 2021, 86: 153567.
20
丁伟超,陈娟,廖浩宇,等.基于网络药理学和体外实验研究血必净注射液治疗脓毒症相关ARDS的作用机制[J].中国中药杂志202348(12):3345-3359.
21
Wang B, Shen J. NF-κB inducing kinase regulates intestinal immunity and homeostasis[J]. Front Immunol, 2022, 13: 895636.
22
Zhou W, Lai X, Wang X, et al. Network pharmacology to explore the anti-inflammatory mechanism of Xuebijing in the treatment of sepsis[J]. Phytomedicine, 2021, 85: 153543.
23
Dostert C, Grusdat M, Letellier E, et al. The TNF family of ligands and receptors: communication modules in the immune system and beyond[J]. Physiol Rev, 2019, 99 (1): 115-160.
24
Zhang Y, Wang J, Liu YM, et al. Analysis of the efficacy and mechanism of action of Xuebijing injection on ARDS using meta-analysis and network pharmacology[J]. Biomed Res Int, 2021, 2021: 8824059.
25
Zhang C, Chen X, Wei T, et al. Xuebijing alleviates LPS-induced acute lung injury by downregulating proinflammatory cytokine production and inhibiting gasdermin-E-mediated pyroptosis of alveolar epithelial cells[J]. Chin J Nat Med, 2023, 21 (8): 576-588.
26
Zhu YP, Speir M, Tan Z, et al. NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils[J]. Sci Adv, 2023, 9 (51): eadj1397.
27
Burgener SS, Schroder K. Neutrophil extracellular traps in host defense[J]. Cold Spring Harb Perspect Biol, 2020, 12 (7): a037028.
28
Abrams ST, Morton B, Alhamdi Y, et al. A novel assay for neutrophil extracellular trap formation independently predicts disseminated intravascular coagulation and mortality in critically ill patients[J]. Am J Respir Crit Care Med, 2019, 200 (7): 869-880.
29
Vasudevan SO, Behl B, Rathinam VA. Pyroptosis-induced inflammation and tissue damage[J]. Semin Immunol, 2023, 69: 101781.
30
Che Y, Chien Y, Zhu Y, et al. GSDMD-dependent neutrophil extracellular traps mediate portal vein thrombosis and associated fibrosis in cirrhosis[J]. Int J Mol Sci, 2024, 25 (16): 9099.
31
Kuang L, Wu Y, Shu J, et al. Pyroptotic macrophage-derived microvesicles accelerate formation of neutrophil extracellular traps via GSDMD-N-expressing mitochondrial transfer during sepsis[J]. Int J Biol Sci, 2024, 20 (2): 733-750.
32
Shang T, Zhang ZS, Wang XT, et al. Xuebijing injection inhibited neutrophil extracellular traps to reverse lung injury in sepsis mice via reducing Gasdermin D[J]. Front Pharmacol, 2022, 13: 1054176.
33
Yu Y, Ma L, Zhang H, et al. EPO could be regulated by HIF-1 and promote osteogenesis and accelerate bone repair[J]. Artif Cells Nanomed Biotechnol, 2020, 48 (1): 206-217.
34
Evans CE. Hypoxia-inducible factor signaling in inflammatory lung injury and repair[J]. Cells, 2022, 11 (2): 183.
35
Ahmed Ali M, Mikhael ES, Abdelkader A, et al. Interleukin-17 as a predictor of sepsis in polytrauma patients: a prospective cohort study[J]. Eur J Trauma Emerg Surg, 2018, 44 (4): 621-626.
36
Kim TO, Park KJ, Cho YN, et al. Altered distribution, activation and increased IL-17 production of mucosal-associated invariant T cells in patients with acute respiratory distress syndrome[J]. Thorax, 2022, 77 (9): 865-872.
37
Zhou W, Fan M, Li X, et al. Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis[J]. World J Emerg Med, 2024, 15 (1): 35-40.
38
Guo LT, Wang SQ, Su J, et al. Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway[J]. J Neuroinflammation, 2019, 16 (1): 95.
39
乔莉,赵超,孙昊,等.参附注射液对脂多糖所致肺泡细胞损伤的保护作用[J/OL].中华危重症医学杂志(电子版)202114(5):362-367.
40
Beard RS Jr, Hoettels BA, Meegan JE, et al. AKT2 maintains brain endothelial claudin-5 expression and selective activation of IR/AKT2/FOXO1-signaling reverses barrier dysfunction[J]. J Cereb Blood Flow Metab, 2020, 40 (2): 374-391.
41
Geng P, Ling BY, Zhang HL, et al. Xuebijing injection ameliorates H2S-induced acute respiratory distress syndrome by promoting claudin-5 expression[J]. Chin J Integr Med, 2022, 28 (2): 116-123.
42
Jin J, Zhao Y, Fang Y, et al. Neutrophil extracellular traps promote the activation of the NLRP3 inflammasome and PBMCs pyroptosis via the ROS-dependent signaling pathway in Kawasaki disease[J]. Int Immunopharmacol, 2025, 145: 113783.
43
Scozzi D, Liao F, Krupnick AS, et al. The role of neutrophil extracellular traps in acute lung injury[J]. Front Immunol, 2022, 13: 953195.
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