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中华危重症医学杂志(电子版) ›› 2025, Vol. 18 ›› Issue (06) : 488 -491. doi: 10.3877/cma.j.issn.1674-6880.2025.06.008

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脓毒症临床计算表型学的研究与分析
乔阳至子1, 邢方亮2, 李超3, 乔庆涛4, 梁腾霄1,5,6,()   
  1. 1100029 北京,北京中医药大学第一临床医学院
    2100176 北京,北京智熵科技有限公司研发部
    3727100 陕西铜川,北京中医药大学孙思邈医院ICU
    4727100 陕西铜川,北京中医药大学孙思邈医院急诊科
    5727100 陕西铜川,北京中医药大学孙思邈医院急诊教研室
    6100700 北京,北京中医药大学东直门医院发热门诊
  • 收稿日期:2025-03-08 出版日期:2025-12-31
  • 通信作者: 梁腾霄
  • 基金资助:
    陕西省中医药管理局2024年度市级中医医院中医药科研能力提升项目(SZY-NLTL-2024-003); 第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号)
  • Received:2025-03-08 Published:2025-12-31
引用本文:

乔阳至子, 邢方亮, 李超, 乔庆涛, 梁腾霄. 脓毒症临床计算表型学的研究与分析[J/OL]. 中华危重症医学杂志(电子版), 2025, 18(06): 488-491.

表1 从大量病历中抽取的脓毒症临床表型集合
图1 脓毒症临床表型的共现网络注:PCT.降钙素原;节点大小表示表型与其他表型的连接能力,连线表示两个表型之间的共现关系,连线粗细代表共现强度
图2 典型脓毒症患者表型序列的病程演进过程注:PCT.降钙素原;从蓝色到红色表示时间进展
1
Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3)[J]. JAMA, 2016, 315 (8): 801-810.
2
中国医疗保健国际交流促进会急诊医学分会,中华医学会急诊医学分会,中国医师协会急诊医师分会,等.中国脓毒症早期预防与阻断急诊专家共识[J].实用休克杂志(中英文)20204(3):168-177,185.
3
Weng L, Zeng XY, Yin P, et al. Sepsis-related mortality in China: a descriptive analysis[J]. Intensive Care Med, 2018, 44 (7): 1071-1080.
4
国家市场监督管理总局,国家标准化管理委员会. GB/T 16751.2-2021 中医临床诊疗术语 第2部分:证候[S].北京:中国标准出版社,2021.
5
Sinha P, Meyer NJ, Calfee CS. Biological phenotyping in sepsis and acute respiratory distress syndrome[J]. Annu Rev Med, 2023, 74: 457-471.
6
王西墨,余剑波,金胜威.脓毒症肺损伤中西医结合诊治专家共识[J].中国中西医结合外科杂志202026(3):400-408.
7
江华.人工智能时代的脓毒症营养支持治疗[J].中华消化外科杂志202524(11):1439-1444.
8
Bycroft C, Freeman C, Petkova D, et al. The UK Biobank resource with deep phenotyping and genomic data[J]. Nature, 2018, 562 (7726): 203-209.
9
Hu Q, Lyon CJ, Fletcher JK, et al. Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses[J]. Acta Pharm Sin B, 2021, 11 (6): 1493-1512.
10
Covert MW, Knight EM, Reed JL, et al. Integrating high-throughput and computational data elucidates bacterial networks[J]. Nature, 2004, 429 (6987): 92-96.
11
van der Meer JH, van der Poll T, van't Veer C. TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis[J]. Blood, 2014, 123 (16): 2460-2469.
12
Gomez H, Ince C, De Backer D, et al. A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury[J]. Shock, 2014, 41 (1): 3-11.
13
Arora S, Dev K, Agarwal B, et al. Macrophages: their role, activation and polarization in pulmonary diseases[J]. Immunobiology, 2018, 223 (4-5): 383-396.
14
Leisman DE, Ronner L, Pinotti R, et al. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes[J]. Lancet Respir Med, 2020, 8 (12): 1233-1244.
15
Joffre J, Hellman J. Oxidative stress and endothelial dysfunction in sepsis and acute inflammation[J]. Antioxid Redox Signal, 2021, 35 (15): 1291-1307.
16
Margraf A, Lowell CA, Zarbock A. Neutrophils in acute inflammation: current concepts and translational implications[J]. Blood, 2022, 139 (14): 2130-2144.
17
Sollis E, Mosaku A, Abid A, et al. The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource[J]. Nucleic Acids Res, 2023, 51 (D1): D977-D985.
18
Dunham-Snary KJ, Wu D, Sykes EA, et al. Hypoxic pulmonary vasoconstriction from molecular mechanisms to medicine[J]. Chest, 2017, 151 (1): 181-192.
19
贾亚娟,蒙钰铭,高志伟,等.血小板与淋巴细胞比值、降钙素原和白细胞介素6联合检测对脓毒症患者预后价值的研究[J/OL].中华危重症医学杂志(电子版)202417(2):118-123.
20
Seymour CW, Kennedy JN, Wang S, et al. Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis[J]. JAMA, 2019, 321 (20): 2003-2017.
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