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中华危重症医学杂志(电子版) ›› 2022, Vol. 15 ›› Issue (06) : 500 -504. doi: 10.3877/cma.j.issn.1674-6880.2022.06.014

综述

铁死亡的发生机制及其在脓毒症中的研究进展
彭适1, 李欢1, 陈娟娟1, 汤冬玲1, 张平安1,()   
  1. 1. 430060 武汉,武汉大学人民医院检验科
  • 收稿日期:2022-09-14 出版日期:2022-12-31
  • 通信作者: 张平安
  • 基金资助:
    国家自然科学基金项目(81773444)
  • Received:2022-09-14 Published:2022-12-31
引用本文:

彭适, 李欢, 陈娟娟, 汤冬玲, 张平安. 铁死亡的发生机制及其在脓毒症中的研究进展[J]. 中华危重症医学杂志(电子版), 2022, 15(06): 500-504.

脓毒症是由失调的宿主反应严重危及生命的急症,是一个全球性的重要健康问题。尽管在护理和治疗方面取得了许多进步,脓毒症的发生率和病死率仍然很高。脓毒症被认为是由于宿主对感染产生了高炎症性免疫反应,但旨在限制过度炎症的大多数临床治疗均未取得实质性的成功。铁死亡是近年来疾病发生发展机制研究中的热门课题,其特征是铁诱导的脂质活性氧(reactive oxygen species,ROS)积累,从而导致细胞内氧化应激。脂质ROS会破坏核酸、蛋白质和细胞膜,最终导致铁死亡。现就铁死亡机制及其与脓毒症关系的研究进展综述如下。

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