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中华危重症医学杂志(电子版) ›› 2026, Vol. 19 ›› Issue (04) : 363 -368. doi: 10.3877/cma.j.issn.1674-6880.2026.04.012

综述

乳酸化修饰:ARDS发病及治疗的新视角
霍如尉, 薛皓月, 李小民, 谢永鹏†()   
  1. 222061 江苏连云港,徐州医科大学附属连云港医院急诊科
  • 收稿日期:2025-05-26 出版日期:2026-08-31
  • 通信作者: 谢永鹏
  • 基金资助:
    江苏省科技厅社会发展面上项目(BE20200670)
  • Received:2025-05-26 Published:2026-08-31
引用本文:

霍如尉, 薛皓月, 李小民, 谢永鹏. 乳酸化修饰:ARDS发病及治疗的新视角[J/OL]. 中华危重症医学杂志(电子版), 2026, 19(04): 363-368.

1
Meyer NJ, Gattinoni L, Calfee CS. Acute respiratory distress syndrome[J]. Lancet, 2021, 398 (10300): 622-637.
2
Fan E, Brodie D, Slutsky AS. Acute respiratory distress syndrome: advances in diagnosis and treatment[J]. JAMA, 2018, 319 (7): 698-710.
3
于瑞璇,刘玲,袁雪燕,等.俯卧位通气在急性呼吸窘迫综合征和新型冠状病毒感染治疗中的研究进展[J/OL].中华危重症医学杂志(电子版),2024,17(6):487-490.
4
Bos LDJ, Ware LB. Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes[J]. Lancet, 2022, 400 (10358): 1145-1156.
5
Dai X, Lv X, Thompson EW, et al. Histone lactylation: epigenetic mark of glycolytic switch[J]. Trends Genet, 2022, 38 (2): 124-127.
6
Wan N, Wang N, Yu S, et al. Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome[J]. Nat Methods, 2022, 19 (7): 854-864.
7
张丽敏,张志明,李兴芳,等.巨噬细胞程序性死亡在急性肺损伤/急性呼吸窘迫综合征中的研究进展[J/OL].中华危重症医学杂志(电子版),2024,17(2):148-154.
8
Zhao W, Yu H, Liu X, et al. Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii[J]. Parasit Vectors, 2022, 15 (1): 180.
9
Gao M, Zhang N, Liang W. Systematic analysis of lysine lactylation in the plant fungal pathogen Botrytis cinerea[J]. Front Microbiol, 2020, 11: 594743.
10
Liu C, Xiao K, Xie L. Advances in the regulation of macrophage polarization by mesenchymal stem cells and implications for ALI/ARDS treatment[J]. Front Immunol, 2022, 13: 928134.
11
Wang J, Yang P, Yu T, et al. Lactylation of PKM2 suppresses inflammatory metabolic adaptation in pro-inflammatory macrophages[J]. Int J Biol Sci, 2022, 18 (16): 6210-6225.
12
Wang N, Wang W, Wang X, et al. Histone lactylation boosts reparative gene activation post-myocardial infarction[J]. Circ Res, 2022, 131 (11): 893-908.
13
Lin J, Liu G, Chen L, et al. Targeting lactate-related cell cycle activities for cancer therapy[J]. Semin Cancer Biol, 2022, 86 (Pt 3): 1231-1243.
14
Gao R, Li Y, Xu Z, et al. Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease[J]. Hepatology, 2023, 78 (6): 1800-1815.
15
Liu X, Zhang Y, Li W, et al. Lactylation, an emerging hallmark of metabolic reprogramming: current progress and open challenges[J]. Front Cell Dev Biol, 2022, 10: 972020.
16
Yang K, Fan M, Wang X, et al. Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis[J]. Cell Death Differ, 2022, 29 (1): 133-146.
17
Vassiliou AG, Tsipilis S, Keskinidou C, et al. Lactate and lactate-to-pyruvate ratio in critically ill COVID-19 patients: a pilot study[J]. J Pers Med, 2022, 12 (2): 171.
18
林逢雨,李毅,宋超,等.急性呼吸窘迫综合征的代谢组学研究进展[J/OL].中华危重症医学杂志(电子版),2021,14(1):71-75.
19
Brooks GA. Lactate as a fulcrum of metabolism[J]. Redox Biol, 2020, 35: 101454.
20
Hagihara H, Shoji H, Otabi H, et al. Protein lactylation induced by neural excitation[J]. Cell Rep, 2021, 37 (2): 109820.
21
Kim DH, Ha EJ, Park SJ, et al. Comparison of prognostic factors between direct and indirect pediatric ARDS[J]. Respir Care, 2020, 65 (12): 1823-1830.
22
Dzsudzsák E, Süto R, Pócsi M, et al. Profiling of lactate dehydrogenase isoenzymes in COVID-19 disease[J]. EJIFCC, 2021, 32 (4): 432-441.
23
Martha JW, Wibowo A, Pranata R. Prognostic value of elevated lactate dehydrogenase in patients withCOVID-19: a systematic review and meta-analysis[J]. Postgrad Med J, 2022, 98 (1160): 422-427.
24
Carpenè G, Onorato D, Nocini R, et al. Blood lactate concentration in COVID-19: a systematic literature review[J]. Clin Chem Lab Med, 2021, 60 (3): 332-337.
25
Yang K, Holt M, Fan M, et al. Cardiovascular dysfunction in COVID-19: association between endothelial cell injury and lactate[J]. Front Immunol, 2022, 13: 868679.
26
Shi R, Lai C, Teboul JL, et al. COVID-19 ARDS is characterized by higher extravascular lung water than non-COVID-19 ARDS: the PiCCOVID study[J]. Crit Care, 2021, 25 (1): 186.
27
Chen L, Huang L, Gu Y, et al. Lactate-lactylation hands between metabolic reprogramming and immunosuppression[J]. Int J Mol Sci, 2022, 23 (19): 11943.
28
Lopez Krol A, Nehring HP, Krause FF, et al. Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells[J]. EMBO Rep, 2022, 23 (12): e54685.
29
Zhang JJ, Dong X, Cao YY, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China[J]. Allergy, 2020, 75 (7): 1730-1741.
30
Panteghini M. Lactate dehydrogenase: an old enzyme reborn as a COVID-19 marker (and not only)[J]. Clin Chem Lab Med, 2020, 58 (12): 1979-1981.
31
Velavan TP, Kieu Linh LT, Kreidenweiss A, et al. Longitudinal monitoring of lactate in hospitalized and ambulatory COVID-19 patients[J]. Am J Trop Med Hyg, 2021, 104 (3): 1041-1044.
32
Visan I. Histone lactylation[J]. Nat Immunol, 2019, 20 (12): 1558.
33
Bartziokas K, Kostikas K. Lactate dehydrogenase, COVID-19 and mortality[J]. Med Clin (Barc), 2021, 156 (1): 37.
34
Zhang H, Li Z, Zheng W, et al. Risk stratification of patients with acute respiratory distress syndrome complicated with sepsis using lactate trajectories[J]. BMC Pulm Med, 2022, 22 (1): 339.
35
Chen XY, Huang MY, Xiao ZW, et al. Lactate dehydrogenase elevations is associated with severity of COVID-19: a meta-analysis[J]. Crit Care, 2020, 24 (1): 459.
36
Han Y, Zhang H, Mu S, et al. Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study[J]. Aging (Albany NY), 2020, 12 (12): 11245-11258.
37
Sipahioglu H, Onuk S. Lactate dehydrogenase/albumin ratio as a prognostic factor in severe acute respiratory distress syndrome cases associated with COVID-19[J]. Medicine (Baltimore), 2022, 101 (38): e30759.
38
Gupta GS. The lactate and the lactate dehydrogenase in inflammatory diseases and major risk factors in COVID-19 patients[J]. Inflammation, 2022, 45 (6): 2091-2123.
39
Khajah MA, Khushaish S, Luqmani YA. Lactate dehydrogenase A or B knockdown reduces lactate production and inhibits breast cancer cell motility in vitro[J]. Front Pharmacol, 2021, 12: 747001.
40
Chen J, Zhang M, Liu Y, et al. Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension[J]. J Mol Cell Biol, 2023, 14 (12): mjac073.
41
Cui H, Xie N, Banerjee S, et al. Lung myofibroblasts promote macrophage profibrotic activity through lactate-induced histone lactylation[J]. Am J Respir Cell Mol Biol, 2021, 64 (1): 115-125.
42
郑永信,黄勇波,刘晓青.氧化应激反应在流感病毒相关ARDS中作用的研究进展[J].中华危重病急救医学,2021,10(33):1272-1276.
43
Moreno-Yruela C, Zhang D, Wei W, et al. Class I histone deacetylases (HDAC1-3) are histone lysine delactylases[J]. Sci Adv, 2022, 8 (3): eabi6696.
44
Yu J, Chai P, Xie M, et al. Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma[J]. Genome Biol, 2021, 22 (1): 85.
45
Wang JH, Mao L, Wang J, et al. Beyond metabolic waste: lysine lactylation and its potential roles in cancer progression and cell fate determination[J]. Cell Oncol (Dordr), 2023, 46 (3): 465-480.
46
Lai FL, Gao F. Auto-Kla: a novel web server to discriminate lysine lactylation sites using automated machine learning[J]. Brief Bioinform, 2023, 24 (2): bbad070.
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