切换至 "中华医学电子期刊资源库"

中华危重症医学杂志(电子版) ›› 2025, Vol. 18 ›› Issue (04) : 333 -336. doi: 10.3877/cma.j.issn.1674-6880.2025.04.012

综述

单细胞转录组测序在脓毒症中的研究进展
刘谱秀1, 龚园其2,()   
  1. 1330006 南昌,南昌大学第二临床医学院研究生院
    2330006 南昌,南昌大学第二附属医院重症医学科
  • 收稿日期:2024-09-09 出版日期:2025-08-31
  • 通信作者: 龚园其
  • Received:2024-09-09 Published:2025-08-31
引用本文:

刘谱秀, 龚园其. 单细胞转录组测序在脓毒症中的研究进展[J/OL]. 中华危重症医学杂志(电子版), 2025, 18(04): 333-336.

1
Hall MJ, Levant S, DeFrances CJ. Trends in inpatient hospital deaths: National Hospital Discharge Survey, 2000-2010[J]. NCHS Data Brief, 2013 (118): 1-8.
2
Xie J, Wang H, Kang Y, et al. The epidemiology of sepsis in Chinese ICUs: a national cross-sectional survey[J]. Crit Care Med, 2020, 48 (3): e209-e218.
3
Farrell JA, Wang Y, Riesenfeld SJ, et al. Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis[J]. Science, 2018, 360 (6392): eaar3131.
4
Zhou F, Wang R, Yuan P, et al. Reconstituting the transcriptome and DNA methylome landscapes of human implantation[J]. Nature, 2019, 572 (7771): 660-664.
5
Zou X, Chen K, Zou J, et al. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection[J]. Front Med, 2020, 14 (2): 185-192.
6
Li Y, Tan R, Chen Y, et al. SC2sepsis: sepsis single-cell whole gene expression database[J]. Database (Oxford), 2022, 2022: baac061.
7
Murao A, Jha A, Aziz M, et al. Transcriptomic profiling of immune cells in murine polymicrobial sepsis[J]. Front Immunol, 2024, 15: 1347453.
8
Wen M, Cai G, Ye J, et al. Single-cell transcriptomics reveals the alteration of peripheral blood mononuclear cells driven by sepsis[J]. Ann Transl Med, 2020, 8 (4): 125.
9
Xie W, Zou S, Dong C, et al. SPI1-mediated autophagy of peripheral blood monocyte cells as a mechanism for sepsis based on single-cell RNA sequencing[J]. Int Immunopharmacol, 2023, 117: 109909.
10
Yang R, Zheng T, Xiang H, et al. Lung single-cell RNA profiling reveals response of pulmonary capillary to sepsis-induced acute lung injury[J]. Front Immunol, 2024, 15: 1308915.
11
He XL, Chen JY, Feng YL, et al. Single-cell RNA sequencing deciphers the mechanism of sepsis-induced liver injury and the therapeutic effects of artesunate[J]. Acta Pharmacol Sin, 2023, 44 (9): 1801-1814.
12
Zhao Q, Ma J, Xiao J, et al. Data driven analysis reveals prognostic genes and immunological targets in human sepsis-associated acute kidney injury[J]. World J Emerg Med, 2024, 15 (2): 91-97.
13
Peng Y, Fang Y, Li Z, et al. Saa3 promotes pro-inflammatory macrophage differentiation and contributes to sepsis-induced AKI[J]. Int Immunopharmacol, 2024, 127: 111417.
14
Xian L, Cheng S, Chen W, et al. Systematic analysis of MASP-1 serves as a novel immune-related biomarker in sepsis and trauma followed by preliminary experimental validation[J]. Front Med (Lausanne), 2024, 11: 1320811.
15
Jiang C, Chen J, Sun T, et al. Unveiling dynamic changes and regulatory mechanisms of T cell subsets in sepsis pathogenesis[J]. Immunotargets Ther, 2024, 13: 29-44.
16
Mo Q, Mo Q, Mo F. Single-cell RNA sequencing and transcriptomic analysis reveal key genes and regulatory mechanisms in sepsis[J]. Biotechnol Genet Eng Rev, 2024, 40 (3): 1636-1658.
17
He H, Huang T, Guo S, et al. Identification of a novel sepsis prognosis model and analysis of possible drug application prospects: based on scRNA-seq and RNA-seq data[J]. Front Immunol, 2022, 13: 888891.
18
Zhang YF, Yi ZJ, Zhang WF, et al. Single-cell sequencing reveals MYOF-enriched monocyte / macrophage subcluster as a favorable prognostic factor in sepsis[J]. Adv Biol (Weinh), 2024, 8 (5): e2300673.
19
Lin Q, Zeng R, Yang J, et al. Prognostic stratification of sepsis through DNA damage response based RiskScore system: insights from single-cell RNA-sequencing and transcriptomic profiling[J]. Front Immunol, 2024, 15: 1345321.
20
Li Y, Yu J, Li R, et al. New insights into the role of mitochondrial metabolic dysregulation and immune infiltration in septic cardiomyopathy by integrated bioinformatics analysis and experimental validation[J]. Cell Mol Biol Lett, 2024, 29 (1): 21.
21
Chen G, Zhang W, Wang C, et al. Screening of four lysosome-related genes in sepsis based on RNA sequencing technology[J]. BMC Immunol, 2023, 24 (1): 50.
22
Qian W, Zhou J, Shou S. Exploration of m6A methylation regulators as epigenetic targets for immunotherapy in advanced sepsis[J]. BMC Bioinformatics, 2023, 24 (1): 257.
23
Chen J, Si J, Li Q, et al. Unlocking the potential of senescence-related gene signature as a diagnostic and prognostic biomarker in sepsis: insights from meta-analyses, single-cell RNA sequencing, and in vitro experiments[J]. Aging (Albany NY), 2024, 16 (4): 3989-4013.
24
Zhao H, Li Y, Sun G, et al. Single-cell transcriptional gene signature analysis identifies IL-17 signaling pathway as the key pathway in sepsis[J]. Immunobiology, 2023, 228 (6): 152763.
25
魏晨如,朱邦晖,王康安,等. 单细胞测序技术在肺部疾病中的研究进展[J/OL]. 中华危重症医学杂志(电子版)2022,15(1):70-74.
No related articles found!
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?