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中华危重症医学杂志(电子版) ›› 2024, Vol. 17 ›› Issue (01) : 73 -77. doi: 10.3877/cma.j.issn.1674-6880.2024.01.013

综述

内皮糖萼在急性呼吸窘迫综合征中的研究进展
祁峰1, 陈建荣1, 张劲松2,()   
  1. 1. 226001 江苏南通,南通市第一人民医院急诊科
    2. 210029 南京,南京医科大学第一附属医院急诊中心
  • 收稿日期:2023-02-14 出版日期:2024-02-29
  • 通信作者: 张劲松
  • Received:2023-02-14 Published:2024-02-29
引用本文:

祁峰, 陈建荣, 张劲松. 内皮糖萼在急性呼吸窘迫综合征中的研究进展[J]. 中华危重症医学杂志(电子版), 2024, 17(01): 73-77.

急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)病死率达35% ~ 45%,新型冠状病毒感染(corona virus disease 2019,COVID-19)所致ARDS病死率更高达52.4%,内皮结构和屏障功能的破坏是ARDS特征性血管通透性增加和肺水肿的主要机制[1-2]。内皮糖萼覆盖于所有内皮细胞表面共同构成内皮屏障,在血管稳态维持及选择性通透中具有关键性作用,并参与调节炎症和凝血及细胞信号转导,已经成为ARDS机制研究与治疗探索的重要方向[3]

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