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中华危重症医学杂志(电子版) ›› 2018, Vol. 11 ›› Issue (06) : 403 -406. doi: 10.3877/cma.j.issn.1674-6880.2018.06.009

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加味麻杏石甘汤对放射性肺纤维化转化生长因子β / Smad信号通路调控的影响
林泽晨1, 吴旭萍2, 林胜友3,()   
  1. 1. 310053 杭州,浙江中医药大学第四临床医学院
    2. 314300 浙江嘉兴,海盐县中医院肿瘤科
    3. 310007 杭州,杭州市中医院肿瘤科
  • 收稿日期:2018-10-15 出版日期:2018-12-01
  • 通信作者: 林胜友
  • 基金资助:
    浙江省自然科学基金项目(LY15H290002)
  • Received:2018-10-15 Published:2018-12-01
引用本文:

林泽晨, 吴旭萍, 林胜友. 加味麻杏石甘汤对放射性肺纤维化转化生长因子β / Smad信号通路调控的影响[J]. 中华危重症医学杂志(电子版), 2018, 11(06): 403-406.

表1 7组小鼠肺泡Ⅱ型上皮细胞TGF-β1表达水平(ng / L,± s)
图1 各组小鼠肺泡Ⅱ型上皮细胞P-Smad2、P-Smad3、snail及E-cadherin蛋白表达情况
1
Giridhar P, Mallick S, Rath GK, et al. Radiation induced lung injury: prediction, assessment and management[J]. Asian Pac J Cancer Prev, 2015, 16 (7): 2613-2617.
2
Chen T, Nie H, Gao X, et al. Epithelial-mesenchymal transition involved in pulmonary fibrosis induced By multi-walled carbon nanotubes via TGF-beta / smad signaling pathway[J]. Toxicol Lett, 2014, 226 (2): 150-162.
3
Balli D, Ustiyan V, Zhang Y, et al. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition[J]. EMBO J, 2013, 32 (2): 231-244.
4
Ding NH, Li JJ, Sun LQ. Molecular mechanisms and treatment of radiation-induced lung fibrosis[J]. Curr Drug Targets, 2013, 14 (11): 1347-1356.
5
林胜友,谢磊,钟亚珍. 加味麻杏石甘汤对急性放射性肺损伤TGF-β / Smad信号通路的影响[J]. 中华中医药杂志, 2015,30(11): 4117-4119.
6
刘平,王宁生,雷燕. 关于血清药理学的若干思考[J]. 中国中西医结合杂志,1999,10(5): 263-266.
7
Nagarajan D, Melo T, Deng Z, et al. ERK / GSK3β / Snail signaling mediates radiation-induced alveolar epithelial-to-mesenchymal transition[J]. Free Radic Biol Med, 2012, 52 (6): 983-992.
8
Vasic L, Durdevic P. Radiation-induced lung damage--etiopathogenesis, clinical features, imaging findings and treatment[J]. Med Pregl, 2012, 65 (7-8): 319-325.
9
Tabata C, Kadokawa Y, Tabata R, et al. All-trans-retinoic acid prevents radiation-or bleomycin-induced pulmonary fibrosis[J]. Am J Respir Crit Care Med, 2006, 174 (12): 1352-1360.
10
于国强,庞立健,付东升,等. 益气养阴活血方治疗肺纤维化患者疗效及对患者炎性因子和肺功能的影响[J]. 世界中医药,2018,13(3): 651-654..
11
代琳,舒静娜,林胜友. 麻杏石甘汤对放射性肺炎急性期的干预作用[J]. 河南中医,2012,32(1): 40-42.
12
陆金华,林胜友,代琳,等. 麻杏石甘汤对放射性肺炎TGF-β1、SMAD7调控的实验研究[J]. 浙江中医药大学学报,2012,36(7): 795-797,802.
13
Kalluri R, Neilson EG. Epithelial-mesenchymal tran-sition and its implications for fibrosis[J]. J Clin Invest, 2003, 112 (12): 1776-1784.
14
Leask A, Abraham DJ. TGF-β signaling and the fi-brotic response[J]. FASEB J, 2004, 18 (7): 816-827.
15
Hong KM, Belperio JA, Keane MP, et al. Differen-tiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma[J]. J Biol Chem, 2007, 282 (31): 22910-22920.
16
Wynn T. Cellular and molecular mechanisms of fib-rosis[J]. J Pathol, 2008, 214 (2): 199-210.
17
Kim KK, Kugler MC, Wolters PJ, et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix[J]. Proc Natl Acad Sci U S A, 2006, 103 (35): 13180-13185.
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