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中华危重症医学杂志(电子版) ›› 2018, Vol. 11 ›› Issue (04) : 265 -269. doi: 10.3877/cma.j.issn.1674-6880.2018.04.010

所属专题： 文献；

荟萃分析

白细胞介素12B rs3212227基因多态性与肝细胞癌发生相关性的Meta分析
周卫江1,†(), 陆军1, 万亚锋1   
  1. 1. 310006　杭州，浙江大学医学院附属杭州市第一人民医院肝胆胰外科
  • 收稿日期:2018-06-10 出版日期:2018-08-01
  • 通信作者: 周卫江

Meta-analysis of the association between interleukin-12B rs3212227 polymorphism and hepatocellular carcinoma

Weijiang Zhou1,†(), Jun Lu1, Yafeng Wan1   

  1. 1. Department of Hepatobiliary and Pancreatic Surgery, Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
  • Received:2018-06-10 Published:2018-08-01
  • Corresponding author: Weijiang Zhou
  • About author:
    Corresponding author: Zhou Weijiang, Email:
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周卫江, 陆军, 万亚锋. 白细胞介素12B rs3212227基因多态性与肝细胞癌发生相关性的Meta分析[J/OL]. 中华危重症医学杂志(电子版), 2018, 11(04): 265-269.

Weijiang Zhou, Jun Lu, Yafeng Wan. Meta-analysis of the association between interleukin-12B rs3212227 polymorphism and hepatocellular carcinoma[J/OL]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2018, 11(04): 265-269.

目的

系统评价白细胞介素12B（IL-12B）rs3212227基因多态性与肝细胞癌发病风险的相关性。

方法

计算机检索CNKI、万方、维普、Pubmed、Medline及OVID等数据库，纳入含有IL-12B rs3212227多态性与肝细胞癌相关性信息的文献。由2位研究者按照纳入标准进行文献筛选及数据提取，使用STATA 14.0软件进行Meta分析，并采用Eggr's检验识别发表偏倚。

结果

共纳入8篇研究，在共显性模型（AC vs. AA）中，IL-12B rs3212227基因多态性与肝细胞癌无明显相关性（Z= 1.84，P= 0.065），而在等位基因模型（C vs. A）、显性模型（CC+ AC vs. AA）、隐性模型（CC vs. AC+ AA）及共显性模型（CC vs. AA）中，C基因型可增加肝细胞癌的发病风险（Z= 2.90，P= 0.004；Z= 3.12，P= 0.002；Z= 2.26，P= 0.024；Z= 2.92，P= 0.003）。分层分析中，以随机人群为来源的研究，在显性模型（CC+ AC vs. AA）中，IL-12B rs3212227基因多态性与肝细胞癌存在相关性[OR= 1.17，95%CI（1.01，1.35），Z= 2.04，P= 0.041]，以医院人群为来源的研究，除共显性模型（AC vs. AA）外[OR= 1.12，95%CI（0.93，1.36），Z= 1.22，P= 0.222]，而等位基因模型（C vs. A）[OR= 1.16，95%CI（1.03，1.30），Z= 2.54，P= 0.011]、显性模型（CC+ AC vs. AA）[OR= 1.22，95%CI（1.04，1.43），Z= 2.39，P= 0.017]，隐性模型（CC vs. AC+ AA）[OR= 1.25，95%CI（1.03，1.53），Z= 2.26，P= 0.024]和共显性模型（CC vs. AA）[OR= 1.37，95%CI（1.09，1.73），Z= 2.69，P= 0.007]模型与肝细胞癌存在相关性。

结论

IL-12B rs3212227基因多态性与肝细胞癌存在相关性，C基因型可增加肝细胞癌的发病风险。

关键词: 癌，肝细胞, 白细胞介素12, 基因多态性, Meta分析
Objective

To systemically explore the association between interleukin 12B (IL-12B) rs3212227 polymorphism and risk of hepatocellular carcinoma.

Method

Systematic searches were conducted in CNKI, Wanfang data, VIP, PubMed, Medline and OVID to collect the articles with relevant information of IL-12B rs3212227 polymorphism and hepatocellular carcinoma. Two reviewers independently screened articles and extracted data according to the inclusion criteria. The STATA 14.0 software was used to perform Meta analysis. The Eggr's test was applied to evaluate the publication bias.

Results

A total of 8 studies were included. In the co-dominant model (AC vs. AA), IL-12B rs3212227 polymorphism was not associated with hepatocellular carcinoma (Z= 1.84, P= 0.065), while in allele model (C vs. A), dominant model (CC+ AC vs. AA), implicit model (CC vs. AC+ AA) and co-dominant model (CC vs. AA), C genotype increased the risk of hepatocellular carcinoma (Z= 2.90, P= 0.004; Z= 3.12, P= 0.002; Z= 2.26, P= 0.024; Z= 2.92, P= 0.003). For the stratified analysis, in the population-based study, IL-12B rs3212227 polymorphism was associated with hepatocellular carcinoma in the dominant model (CC+ AC vs. AA)[OR= 1.17, 95%CI(1.01, 1.35), Z= 2.04, P= 0.041], and in the hospital-based study, IL-12B rs3212227 polymorphism was associated with hepatocellular carcinoma in allele model (C vs. A)[OR= 1.16, 95%CI(1.03, 1.30), Z= 2.54, P= 0.011], dominant model (CC+ AC vs. AA)[OR= 1.22, 95%CI (1.04, 1.43), Z= 2.39, P= 0.017], implicit model (CC vs. AC+ AA)[OR= 1.25, 95%CI (1.03, 1.53), Z= 2.26, P= 0.024] and co-dominant model (CC vs. AA)[OR= 1.37, 95%CI (1.09, 1.73), Z= 2.69, P= 0.007], except for the co-dominant model (AC vs. AA)[OR= 1.12, 95%CI (0.93, 1.36), Z= 1.22, P= 0.222].

Conclusion

IL-12B rs3212227 polymorphism is associated with hepatocellular carcinoma and the C genotype can increase the hepatocellular carcinoma risk.

Key words: Carcinoma, hepatocellular, Interleukin-12, Polymorphism, Meta-analysis
表1 病例组和对照组中IL-12B rs3212227基因的分布
第一作者 种族 对照来源 病例组 对照组 HWE
AA AC CC AA AC CC
Nieters等[14] 亚洲人 医院人群 56 NA NA 72 NA NA -
Ognjanovic等[15] 高加索人 随机人群 57 NA NA 128 NA NA -
刘莉等[16] 亚洲人 随机人群 162 271 100 169 259 86 0.43
Liu等[17] 亚洲人 随机人群 249 422 160 272 414 158 0.98
杨艳等[18] 亚洲人 医院人群 156 309 143 195 302 115 0.92
Saxena等[19] 亚洲人 随机人群 19 31 9 63 71 14 0.35
Tan等[20] 亚洲人 医院人群 104 201 90 200 347 139 0.61
Elsayed等[21] 非洲人 医院人群 41 22 15 38 40 14 0.52
图1 白细胞介素12B rs3212227基因多态性与肝细胞癌相关性的森林图
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